公开(公告)号：US09475774B2

公开(公告)日：2016-10-25

申请号：US14453220

申请日：2014-08-06

Applicant: Technion Research and Development Foundation Ltd.

Inventor： Alex M. Szpilman ,  Michal Amar

IPC: C07D221/14 ,  B01J31/02 ,  C07C45/39

CPC classification number: C07D221/14 ,  B01J31/0244 ,  C07C45/39

Abstract: Novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and the use of such compounds, inter alia, for oxidation of primary and secondary alcohols to aldehydes and ketones, respectively; resolution of racemic alcohols; desymmetrization of meso-alcohol; as radicals and spin trapping reagents; and as polymerization agents. Processes for preparing the novel nitroxyl/oxoammonium/hydroxylamine compounds from the corresponding amines, and certain novel amine derivatives and their uses. The compounds and amine precursors are useful as ligands for transition metals and as organocatalysts in e.g., aldol reactions.

Abstract translation: 新的α-氢取代的硝酰基化合物及其相应的氧化（氧代铵阳离子）和还原（羟胺）形式，以及这些化合物尤其用于将伯醇和仲醇氧化成醛和酮的用途; 拆分外消旋醇; 内消旋醇的对称性; 作为自由基和自旋捕获试剂; 并作为聚合剂。 从相应的胺制备新的硝酰基/氧代铵/羟胺化合物的方法，以及某些新的胺衍生物及其用途。 化合物和胺前体可用作过渡金属的配体，并且可用作例如醛醇反应中的有机催化剂。

公开(公告)号：US20140350258A1

公开(公告)日：2014-11-27

申请号：US14453220

申请日：2014-08-06

Applicant: Technion Research and Development Foundation Ltd.

Inventor： Alex M. Szpilman ,  Michal Amar

IPC: C07D221/14 ,  B01J31/02 ,  C07C45/39

CPC classification number: C07D221/14 ,  B01J31/0244 ,  C07C45/39

Abstract: Novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and the use of such compounds, inter alia, for oxidation of primary and secondary alcohols to aldehydes and ketones, respectively; resolution of racemic alcohols; desymmetrization of meso-alcohol; as radicals and spin trapping reagents; and as polymerization agents. Processes for preparing the novel nitroxyl/oxoammonium/hydroxylamine compounds from the corresponding amines, and certain novel amine derivatives and their uses. The compounds and amine precursors are useful as ligands for transition metals and as organocatalysts in e.g., aldol reactions.

Abstract translation: 新的α-氢取代的硝酰基化合物及其相应的氧化（氧代铵阳离子）和还原（羟胺）形式，以及这些化合物尤其用于将伯醇和仲醇氧化成醛和酮的用途; 拆分外消旋醇; 内消旋醇的对称性; 作为自由基和自旋捕获试剂; 并作为聚合剂。 从相应的胺制备新的硝酰基/氧代铵/羟胺化合物的方法，以及某些新的胺衍生物及其用途。 化合物和胺前体可用作过渡金属的配体，并且可用作例如醛醇反应中的有机催化剂。