公开(公告)号：US20230364298A1

公开(公告)日：2023-11-16

申请号：US18152456

申请日：2023-01-10

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Azadeh Timnak ,  Peter I. Lelkes ,  Yah-el H. Har-el

IPC: A61L27/22 ,  A61L27/26 ,  A61L27/56 ,  D01D5/00

CPC classification number: A61L27/227 ,  A61L27/26 ,  A61L27/56 ,  D01D5/003 ,  D10B2509/022

Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.

公开(公告)号：US11547776B2

公开(公告)日：2023-01-10

申请号：US16608381

申请日：2018-04-26

Applicant: Temple University—Of The Commonwealth System of Higher Education

Inventor： Azadeh Timnak ,  Peter I. Lelkes ,  Yah-el H. Har-el

IPC: A61L27/22 ,  A61L27/26 ,  A61L27/56 ,  D01D5/00

Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.

公开(公告)号：US20210046213A1

公开(公告)日：2021-02-18

申请号：US16608381

申请日：2018-04-26

Applicant: Temple University-Of The Commonwealth System of Higher Education

Inventor： Azadeh Timnak ,  Peter I. Lelkes ,  Yah-el H. Har-el

IPC: A61L27/22 ,  A61L27/26 ,  A61L27/56 ,  D01D5/00

Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.

公开(公告)号：US20200038248A1

公开(公告)日：2020-02-06

申请号：US16339955

申请日：2017-10-05

Applicant: Temple University- Of the Commonwealth System of Higher Education

Inventor： Azadeh Timnak ,  Jonathan A. Gerstenhaber ,  Yah-el H. Har-el ,  Peter I. Lelkes

IPC: A61F13/00 ,  A61M1/00 ,  A61F13/36 ,  A61L15/40 ,  A61L15/44 ,  A61F13/15

Abstract: The present invention provides methods for improving negative pressure wound therapy. The application of negative pressure to a wound bed with a biodegradable biocompatible fibrous scaffold facilitates cell infiltration into the scaffold serving as a 3D structure, as opposed to solely application of the scaffold without any pressure, which shows minimal cell penetration. In vitro studies show that infiltration of immune cells into scaffolds paves the way for their polarization towards the phenotype pertinent to the remodeling stage 2. The cell penetration factor causes less intense immune response of the host body, leading the inflammation to proceed to the remodeling stage.