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公开(公告)号：US11077169B2
公开(公告)日：2021-08-03
申请号：US15746508
申请日：2016-07-21
发明人： Peter I. Lelkes , Yah-El H. Har-el , Cezary Marcinkiewicz , Philip Lazarovici , Sogol Moaiyed Baharlou , Jonathan A. Gerstenhaber
IPC分类号： A61L27/38 , A61L27/18 , A61F2/02 , A61K47/42 , A61K9/70 , A61K38/16 , A61L27/54 , A61L26/00 , A61L15/32 , A61L15/44 , A61L27/22 , A61L15/26 , A61P17/02 , A61L27/52
摘要： Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.
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公开(公告)号：US12031252B2
公开(公告)日：2024-07-09
申请号：US15764476
申请日：2016-09-29
CPC分类号： D04H1/728 , D01F1/10 , A61L2400/12 , D01D5/003 , D01D5/0061 , D01D5/14 , D10B2509/00
摘要： The present invention provides portable devices and systems for electrofocused blow spinning, and methods for using the same. The devices of the invention are convenient to carry and use and are able to aerodynamically spin a variety of materials in a mobile setting.
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公开(公告)号：US20170203009A1
公开(公告)日：2017-07-20
申请号：US15326189
申请日：2015-07-14
CPC分类号： A61L27/58 , A61L27/18 , A61L27/56 , A61L2430/12 , C12N5/0664 , C12N2533/40
摘要： The present invention relates to biomimetic scaffolds, methods for making the same, and methods for using the same. The scaffolds comprise a plurality of graded or tapered microchannels that provide spatial control for cell penetration. The scaffolds are useful for regenerating missing interface tissue between two adjacent tissues, or regeneration and integration of two adjacent tissues directly.
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公开(公告)号：US11547776B2
公开(公告)日：2023-01-10
申请号：US16608381
申请日：2018-04-26
发明人： Azadeh Timnak , Peter I. Lelkes , Yah-el H. Har-el
摘要： The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.
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公开(公告)号：US20220211804A1
公开(公告)日：2022-07-07
申请号：US17392024
申请日：2021-08-02
发明人： Peter I. Lelkes , Yah-el H. Har-el , Cezary Marcinkiewicz , Philip Lazarovici , Sogol Moaiyed Baharlou , Jonathan A. Gerstenhaber
IPC分类号： A61K38/16 , A61L27/18 , A61L27/54 , A61L26/00 , A61L15/32 , A61L15/44 , A61L27/22 , A61L15/26 , A61P17/02 , A61L27/52
摘要： Compositions and methods for the promotion of wound healing and tissue regeneration are described. The compositions and methods make use of water-soluble soy protein isolates (WSsoy), Fraction 5, Fraction 9, and/or bioactive peptide components of soy protein isolates. The invention also relates to the unexpected discovery that purified WSsoy forms gel-like matrices when suspended within certain concentration ranges in an aqueous environment. The compositions of the invention comprising WSsoy promote natural healing and have a low risk profile.
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公开(公告)号：US20210046213A1
公开(公告)日：2021-02-18
申请号：US16608381
申请日：2018-04-26
发明人： Azadeh Timnak , Peter I. Lelkes , Yah-el H. Har-el
摘要： The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.
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公开(公告)号：US20200038248A1
公开(公告)日：2020-02-06
申请号：US16339955
申请日：2017-10-05
摘要： The present invention provides methods for improving negative pressure wound therapy. The application of negative pressure to a wound bed with a biodegradable biocompatible fibrous scaffold facilitates cell infiltration into the scaffold serving as a 3D structure, as opposed to solely application of the scaffold without any pressure, which shows minimal cell penetration. In vitro studies show that infiltration of immune cells into scaffolds paves the way for their polarization towards the phenotype pertinent to the remodeling stage 2. The cell penetration factor causes less intense immune response of the host body, leading the inflammation to proceed to the remodeling stage.
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公开(公告)号：US20230364298A1
公开(公告)日：2023-11-16
申请号：US18152456
申请日：2023-01-10
发明人： Azadeh Timnak , Peter I. Lelkes , Yah-el H. Har-el
CPC分类号： A61L27/227 , A61L27/26 , A61L27/56 , D01D5/003 , D10B2509/022
摘要： The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.
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9.发明申请公开(公告)号：US20180282167A1
公开(公告)日：2018-10-04
申请号：US15765108
申请日：2016-09-30
发明人： Sean M. Devlin , Peter I. Lelkes
摘要： Described herein are improved surgical fixation devices and methods of making the same. The methods comprise mechanochemical processing and vacuum annealing of biocompatible polymer-nanomaterial mixtures to form composites exhibiting superior mechanical properties.
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公开(公告)号：US10005219B2
公开(公告)日：2018-06-26
申请号：US14913915
申请日：2014-08-22
CPC分类号： B29C48/142 , A61F2/3094 , A61F2/32 , A61F2002/30978 , A61F2002/30983 , A61F2002/30985 , A61F2240/001 , B05D1/045 , B29C48/05 , B29C48/154 , B29K2025/06 , B29K2995/0056 , B29L2031/7532 , D01D5/0061
摘要： The present invention includes a robotic system for the enhanced automation, manipulation, and control of electroprocessing in two or three dimensions. In one embodiment, the system includes a sealed chamber devoid of any electrical or conductive components which would interfere with the electrical field and eventual material fabrication, while still allowing for two-dimensional and three-dimensional robot motion. In certain embodiments, the system of the invention produces materials or scaffolds with complex shapes, including materials with ridges, valleys, curves, and the like, which are difficult or impossible to construct using traditional systems.
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