公开(公告)号：US4713247A

公开(公告)日：1987-12-15

申请号：US615242

申请日：1984-05-30

申请人： Teruo Sakamoto ,  Sadao Kawai ,  Kinzaburo Noda ,  Toyohiko Takeda ,  Hiroshi Kato

发明人： Teruo Sakamoto ,  Sadao Kawai ,  Kinzaburo Noda ,  Toyohiko Takeda ,  Hiroshi Kato

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48 ,  A61K9/50 ,  A61K9/56 ,  A61K31/545 ,  A61P31/04 ,  A61K9/62 ,  A61K9/58 ,  A61K31/675 ,  A61K31/78

CPC分类号： A61K31/545 ,  A61K9/5084

摘要： Highly potent long-acting formulation of cefaclor for treating bacterial infections in human or animals, comprising a rapid-release and a slow-release component at a ratio of about 3:7 to about 5:5 by potency of cefaclor, convenient for administration or carrying about.

摘要翻译： 用于治疗人或动物中的细菌感染的高效长效制剂，其包含通过头孢克洛的效力以约3:7至约5:5的比例的快速释放和缓释组分，方便给药或 携带

公开(公告)号：US4720387A

公开(公告)日：1988-01-19

申请号：US617567

申请日：1984-06-05

申请人： Teruo Sakamoto ,  Sadao Kawai ,  Kinzaburo Noda ,  Toyohiko Takeda ,  Toshihiro Ogura

发明人： Teruo Sakamoto ,  Sadao Kawai ,  Kinzaburo Noda ,  Toyohiko Takeda ,  Toshihiro Ogura

IPC分类号： C07D213/75 ,  A61K9/00 ,  A61K9/36 ,  A61K9/50 ,  A61K9/62 ,  A61K31/44 ,  A61K31/4409 ,  A61K9/24

CPC分类号： A61K31/44 ,  A61K9/5084

摘要： Highly effective and orally administrable sustained-release preparation of an antihypertensive agent, pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine) comprising a rapid-release and a slow-release component at a ratio of about 7:3 to about 1:9 by pinacidil weight.

摘要翻译： 高效口服给药的抗高血压药缓释制剂，包含快速释放组分和缓释组分的pinacidil（N“ - 氰基-N-4-吡啶基-N'-1,2,2-三甲基丙基胍） 其比例为约7:3至约1:9。

公开(公告)号：US4828840A

公开(公告)日：1989-05-09

申请号：US66512

申请日：1987-06-26

申请人： Teruo Sakamoto ,  Toyohiko Takeda ,  Yusuke Suzuki ,  Kinzaburo Noda ,  Toshiro Fujii

发明人： Teruo Sakamoto ,  Toyohiko Takeda ,  Yusuke Suzuki ,  Kinzaburo Noda ,  Toshiro Fujii

IPC分类号： A61K9/54 ,  A61K9/22 ,  A61K9/50 ,  A61K9/52

CPC分类号： A61K9/5078

摘要： Sustained-release formulations which can release a water-soluble active ingredient or ingredients at the zero-order over a long period of time, comprising:a. an inert core,b. a powder-coating layer containing a water-soluble active ingredient or ingredients,c. a powder-coating layer of practically water-repellent material, andd. a film-coating layer composed of practically pH-independent and water-insoluble film-coating material.

公开(公告)号：US4176175A

公开(公告)日：1979-11-27

申请号：US803853

申请日：1977-06-06

申请人： Hideyuki Maekawa ,  Kinzaburo Noda ,  Noboru Hoshi

发明人： Hideyuki Maekawa ,  Kinzaburo Noda ,  Noboru Hoshi

IPC分类号： A61K9/28 ,  A61K9/36 ,  A61K47/38

CPC分类号： A61K9/2866 ,  A61K9/2826

摘要： The sugar-coated solid dosage forms have improved disintegrability even in a neutral medium after prolonged storage, with sugar-coating layers having excellent mechanical strengths. The coating layer that is in direct contact with the surface of the solid dosage form contains a water-insoluble hydroxypropyl cellulose with a relatively low content of hydroxypropoxy groups, say, from 4 to 16% by weight. The hydroxypropyl cellulose is used by being suspended in the coating syrup or mixed in the dusting powder for purposes of subcoating. It is also possible to use the hydroxypropyl cellulose in the form of suspension to form a smoothing coat.

摘要翻译： 糖衣固体剂型在长时间保存后即使在中性培养基中也具有改善的崩解性，糖衣层具有优异的机械强度。 与固体剂型表面直接接触的涂层含有羟丙氧基含量相对较低的水不溶性羟丙基纤维素，例如4至16重量％。 羟丙基纤维素通过悬浮在涂布糖浆中或混合在除尘粉末中以用于底涂层而使用。 还可以使用悬浮液形式的羟丙基纤维素来形成平滑涂层。