公开(公告)号：US08772475B2

公开(公告)日：2014-07-08

申请号：US12743777

申请日：2008-11-28

申请人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

发明人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

IPC分类号： C07D225/00

CPC分类号： C07F5/003 ,  A61K49/106 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D405/14

摘要： A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

摘要翻译： 由（-N-（CH 2）n - ）k表示的环状结构的核心与核心中所有氮原子上具有特定支化结构的树枝状大分子侧链结合，生成具有特定结构的化合物， 具有T1还原效果的金属络合物，所得化合物与具有T1还原效果的金属离子配位，得到显示出优异的T1还原效果的金属络合物，其可用作有机组分 MRI造影剂和使用其的MRI造影剂。

公开(公告)号：US20110028713A1

公开(公告)日：2011-02-03

申请号：US12743777

申请日：2008-11-28

申请人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

发明人： Teruyuki Kondo ,  Hiroshi Tsujita ,  Zainul Abedin Siddique ,  Shingo Matsuki ,  Hiroki Miura ,  Hidehito Tochio ,  Tetsuya Matsuda ,  Michiko Narazaki ,  Hidetoshi Tsuzuki ,  Katsuaki Kuge ,  Yoshinori Tomida ,  Kimihiro Yoshimura ,  Tetsuya Yano

IPC分类号： C07F5/00 ,  C07D405/14 ,  C07D407/12 ,  C07D255/02

CPC分类号： C07F5/003 ,  A61K49/106 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00 ,  C07D405/14

摘要： A core of a cyclic structure represented by (—N—(CH2)n—)k is bonded to a dendrimer-type side chain with a specific branched structure at all nitrogen atoms in the core to produce a compound with a specific structure for producing a metal complex that exhibits a T1-reducing effect, and the resulting compound is coordinated to a metal ion that has a T1-reducing effect to obtain a metal complex that exhibits an excellent T1-reducing effect which is useful as an effective component of an MRI contrast agent and an MRI contrast agent using the same.

摘要翻译： 由（-N-（CH 2）n - ）k表示的环状结构的核心与核心中所有氮原子上具有特定支化结构的树枝状大分子侧链结合，生成具有特定结构的化合物， 具有T1还原效果的金属络合物，所得化合物与具有T1还原效果的金属离子配位，得到显示出优异的T1还原效果的金属络合物，其可用作有机组分 MRI造影剂和使用其的MRI造影剂。