公开(公告)号：US20150119318A1

公开(公告)日：2015-04-30

申请号：US14327287

申请日：2014-07-09

申请人： The Administrators of the Tulane Educational Fund

发明人： Lilia I. Melnik ,  Robert F. Garry ,  Cindy A. Morris

IPC分类号： C07K14/005

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  C07K14/045 ,  C12N2710/16122 ,  C12N2710/16133

摘要： The present invention provides an isolated peptide having an amino acid residue sequence that comprises at least one human cytomegalovirus glycoprotein B (HCMV-gB) sequence segment, each HCMV-gB sequence segment consisting of at least 8 and not more than 60 consecutive amino acid residues from residues 146 to 315, residues 476 to 494 of SEQ ID NO: 1, or from a sequence variant of residues 146 to 315 or 476 to 494 of SEQ ID NO: 1 that has at least 70% sequence identity thereto. The peptides of the invention are useful for treating, preventing, or inhibiting a herpesvirus (e.g., Herpes Simplex Virus-1, Human Cytomegalovirus, and the like) infection in a subject.

摘要翻译： 本发明提供了具有包含至少一种人巨细胞病毒糖蛋白B（HCMV-gB）序列片段的氨基酸残基序列的分离肽，每个HCMV-gB序列片段由至少8个且不超过60个连续氨基酸残基组成 来自SEQ ID NO：1的残基146至315，SEQ ID NO：1的残基476至494或与SEQ ID NO：1具有至少70％序列同一性的SEQ ID NO：1的残基146至315或476至494的序列变体。 本发明的肽可用于治疗，预防或抑制受试者中疱疹病毒（例如，单纯疱疹病毒-1，人巨细胞病毒等）感染。

公开(公告)号：US09434769B2

公开(公告)日：2016-09-06

申请号：US14327287

申请日：2014-07-09

申请人： The Administrators of the Tulane Educational Fund

发明人： Lilia I. Melnik ,  Robert F. Garry ,  Cindy A. Morris

IPC分类号： C07K14/045 ,  A61P31/22 ,  A61K39/245 ,  C07K14/005 ,  A61K39/12 ,  A61K39/00 ,  A61K38/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/245 ,  C07K14/045 ,  C12N2710/16122 ,  C12N2710/16133

摘要： The present invention provides an isolated peptide having an amino acid residue sequence that comprises at least one human cytomegalovirus glycoprotein B (HCMV-gB) sequence segment, each HCMV-gB sequence segment consisting of at least 8 and not more than 60 consecutive amino acid residues from residues 146 to 315, residues 476 to 494 of SEQ ID NO: 1, or from a sequence variant of residues 146 to 315 or 476 to 494 of SEQ ID NO: 1 that has at least 70% sequence identity thereto. The peptides of the invention are useful for treating, preventing, or inhibiting a herpesvirus (e.g., Herpes Simplex Virus-1, Human Cytomegalovirus, and the like) infection in a subject.

摘要翻译： 本发明提供了具有包含至少一种人巨细胞病毒糖蛋白B（HCMV-gB）序列片段的氨基酸残基序列的分离肽，每个HCMV-gB序列片段由至少8个且不超过60个连续氨基酸残基组成 来自SEQ ID NO：1的残基146至315，SEQ ID NO：1的残基476至494或与SEQ ID NO：1具有至少70％序列同一性的SEQ ID NO：1的残基146至315或476至494的序列变体。 本发明的肽可用于治疗，预防或抑制受试者中疱疹病毒（例如，单纯疱疹病毒-1，人巨细胞病毒等）感染。