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公开(公告)号：US20230333107A1
公开(公告)日：2023-10-19
申请号：US17927178
申请日：2021-05-20
发明人： Stephen HARDING , David BARNIDGE , Charles DE ROHAN , Richard HUGHES , Sabah PASHA , Simon NORTH , Roshani PATEL , Gregg WALLIS
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56983 , G01N33/6851 , G01N2333/165 , G01N2469/20
摘要： This invention provides a method of identifying or characterising an immune response in a subject comprising: (a) contacting a sample containing immunoglobulins from the subject with at least one antigen immobilised on a support; (b) washing unbound, non-antigen specific immunoglobulins from the support to leave antigen-specific immunoglobulins bound to the antigen on the support; (c) optionally eluting the antigen-specific immunoglobulins from the antigen on the support; and (d) subjecting the antigen-specific immunoglobulins to mass spectrometry to identify two or more different antigen specific immunoglobulin classes, subclasses and/or light chain types.
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公开(公告)号：US20230080943A1
公开(公告)日：2023-03-16
申请号：US17990554
申请日：2022-11-18
发明人： Gregg WALLIS , Stephen HARDING , Richard HUGHES
摘要： The application provides a method of identifying or monitoring a plasma cell associated disease, comprising purifying immunoglobulin free light chains (FLCs) from a sample from a subject with anti-FLC specific antibodies or fragments thereof and subjecting the purified sample to a mass spectrometry technique to identify the presence of one or more peaks corresponding to one or more monoclonal FLCs in the sample.
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3.发明申请公开(公告)号：US20220390450A1
公开(公告)日：2022-12-08
申请号：US17774086
申请日：2020-11-03
发明人： Gregg WALLIS , Stephen HARDING , Richard HUGHES
IPC分类号： G01N33/574 , G01N33/68
摘要： Method of Detecting or Monitoring Minimal Residual Disease The application describes a method of identifying minimal residual disease (MRD) in a monoclonal gammopathy patient, comprising detecting the presence or absence of a monoclonal free light chain (FLC) in a sample from the patient by mass spectrometry (MS).
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