公开(公告)号：US20240398708A1

公开(公告)日：2024-12-05

申请号：US18540656

申请日：2023-12-14

Applicant: The Board of Regents of The University of Texas System

Inventor： Shao-Ling HUANG ,  Melvin E. KLEGERMAN ,  Yong-Jian GENG ,  Hyunggun KIM ,  David D. MCPHERSON

IPC: A61K9/127 ,  A61K9/00 ,  A61K33/00 ,  A61K41/00

Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.

公开(公告)号：US20210378959A1

公开(公告)日：2021-12-09

申请号：US17229627

申请日：2021-04-13

Applicant: The Board of Regents of The University of Texas System

Inventor： Shao-Ling HUANG ,  Melvin E. KLEGERMAN ,  Yong-Jian GENG ,  Hyunggun KIM ,  David D. MCPHERSON

IPC: A61K9/127 ,  A61K33/00 ,  A61K9/00 ,  A61K41/00

Abstract: Methods for the treatment of stroke, such as stroke of undetermined origin, by administration of xenon (Xe)-loaded liposome compositions are provided. In some aspects, Xe is encapsulated in echogenic liposomes and release of Xe can be enhanced by application of ultrasound stimulation. Compositions for use in treating stroke, such as liposomes loaded with Xe or Xe in combination with H2 or H2S, are also provided.