公开(公告)号：US10420720B2

公开(公告)日：2019-09-24

申请号：US15585980

申请日：2017-05-03

Applicant: The Board of Regents of the University of Texas System

Inventor： Christopher C. Capelli ,  Phillip C. Phan ,  Allen W. Burton

IPC: A61K31/02 ,  A61K31/08 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K47/20 ,  A61K47/22

Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.

公开(公告)号：US10799466B2

公开(公告)日：2020-10-13

申请号：US16434541

申请日：2019-06-07

Applicant: The Board of Regents of the University of Texas System

Inventor： Phillip C. Phan ,  Allen W. Burton

IPC: A61K9/19 ,  A61K9/08 ,  A61K31/07 ,  A61K31/02 ,  A61K9/00

Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic such as a halogenated ether compound in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered to the subject to anesthetize the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, xenon, and mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.