公开(公告)号：US10420720B2

公开(公告)日：2019-09-24

申请号：US15585980

申请日：2017-05-03

Applicant: The Board of Regents of the University of Texas System

Inventor： Christopher C. Capelli ,  Phillip C. Phan ,  Allen W. Burton

IPC: A61K31/02 ,  A61K31/08 ,  A61K9/00 ,  A61K9/107 ,  A61K9/127 ,  A61K47/20 ,  A61K47/22

Abstract: The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery. In certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.