公开(公告)号：US20210290652A1

公开(公告)日：2021-09-23

申请号：US17200539

申请日：2021-03-12

Applicant: The Board of Regents of the University of Texas System

Inventor： Jerry Shay ,  Yang-Xin Fu ,  Ilgen Mender ,  Anli Zhang

IPC: A61K31/7076 ,  A61P35/00 ,  C07K16/28 ,  A61N5/00

Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2′-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. eads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.

公开(公告)号：US12097213B2

公开(公告)日：2024-09-24

申请号：US17200539

申请日：2021-03-12

Applicant: The Board of Regents of the University of Texas System

Inventor： Jerry Shay ,  Yang-Xin Fu ,  Ilgen Mender ,  Anli Zhang

IPC: A61K31/7076 ,  A61N5/00 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K31/7076 ,  A61N5/00 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827

Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2′-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. Leads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.