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1.发明申请公开(公告)号：US20210290652A1
公开(公告)日：2021-09-23
申请号：US17200539
申请日：2021-03-12
Inventor： Jerry Shay , Yang-Xin Fu , Ilgen Mender , Anli Zhang
IPC: A61K31/7076 , A61P35/00 , C07K16/28 , A61N5/00
Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2′-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. eads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.
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2.发明授权公开(公告)号：US12097213B2
公开(公告)日：2024-09-24
申请号：US17200539
申请日：2021-03-12
Inventor： Jerry Shay , Yang-Xin Fu , Ilgen Mender , Anli Zhang
IPC: A61K31/7076 , A61N5/00 , A61P35/00 , C07K16/28
CPC classification number: A61K31/7076 , A61N5/00 , A61P35/00 , C07K16/2818 , C07K16/2827
Abstract: Disclosed herein are methods of treatments with a telomerase-mediated telomere-targeting drug, 6-thio-2′-deoxyguanosine (6-thio-dG), checkpoint inhibitors and/or radiation therapy for treating cancers. Leads to tumor regression in innate and adaptive immune-dependent manners in syngeneic and humanized mouse cancer models.
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公开(公告)号：US11376324B2
公开(公告)日：2022-07-05
申请号：US16081911
申请日：2017-03-02
Inventor： Jinming Gao , Zhijian Chen , Min Luo , Zhaohui Wang , Hua Wang , Haocheng Cai , Gang Huang , Yang-Xin Fu
IPC: A61K39/39 , A61K39/00 , A61K9/51 , A61K47/32 , A61K47/58 , B82Y5/00 , A61K9/00 , A61K45/06 , A61K39/145
Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.
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