公开(公告)号：US12251383B2

公开(公告)日：2025-03-18

申请号：US17469457

申请日：2021-09-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Alemayehu Gorfe Abebe ,  Michael J. McCarthy ,  Cynthia V. Pagba ,  Priyanka Prakash Srivastava

IPC: A61K31/519

Abstract: In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230124492A1

公开(公告)日：2023-04-20

申请号：US17784078

申请日：2020-12-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Cynthia V. Pagba ,  Alemayehu Gorfe Abebe ,  Scott R. Gilbertson ,  Kasuni Dilsha

IPC: C07D487/04 ,  A61P35/00 ,  A61K45/06 ,  A61K31/519

Abstract: In one aspect, the disclosure relates to compounds useful as inhibitors of mutant KRAS proteins, methods of making the same, pharmaceutical compositions comprising the same, and methods of treating cancers associated with mutated forms of KRAS using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.