公开(公告)号：US12251383B2

公开(公告)日：2025-03-18

申请号：US17469457

申请日：2021-09-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Alemayehu Gorfe Abebe ,  Michael J. McCarthy ,  Cynthia V. Pagba ,  Priyanka Prakash Srivastava

IPC: A61K31/519

Abstract: In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20210401845A1

公开(公告)日：2021-12-30

申请号：US17469457

申请日：2021-09-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Alemayehu Gorfe Abebe ,  Michael J. McCarthy ,  Cynthia V. Pagbal ,  Priyaka Prakash Srivastava

IPC: A61K31/519

Abstract: In one aspect, the disclosure relates to compounds that are inhibitors of KRAS, and the disclosed compounds are allosteric inhibitors of KRAS which render them extremely useful for therapeutic intervention in a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, e.g., cancer. In various aspects, the disclosed compounds are substituted 7-(piperazin-1-yl)pyrazolo[1,5-a]pyrimidine analogs. In further aspects, the disclosed compounds can be used in methods of treating a cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.