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公开(公告)号：US09801944B2
公开(公告)日：2017-10-31
申请号：US15261245
申请日：2016-09-09
Inventor： Daniel J. Siegwart , Jing Hao , Kejin Zhou , Jason Miller , Petra Kos , Lian Xue
IPC: A61K47/34 , C07H21/02 , C07H21/04 , A61K47/28 , A61K47/22 , C08G65/48 , C08G63/91 , A61K31/713 , A61K9/00 , A61K47/24 , C08G63/688 , C12N15/113 , A61K9/51
CPC classification number: A61K47/34 , A61K9/0019 , A61K9/5153 , A61K31/713 , A61K47/22 , A61K47/24 , A61K47/28 , C08G63/688 , C08G63/912 , C08G65/48 , C12N15/113 , C12N2310/14
Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
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公开(公告)号：US09517270B2
公开(公告)日：2016-12-13
申请号：US14962422
申请日：2015-12-08
Inventor： Daniel J. Siegwart , Jing Hao , Kejin Zhou , Jason Miller , Petra Kos , Lian Xue
IPC: A61K47/34 , C07H21/02 , C07H21/04 , A61K47/28 , A61K47/24 , A61K47/22 , C08G65/48 , C08G63/91 , A61K31/713
CPC classification number: A61K47/34 , A61K9/0019 , A61K9/5153 , A61K31/713 , A61K47/22 , A61K47/24 , A61K47/28 , C08G63/688 , C08G63/912 , C08G65/48 , C12N15/113 , C12N2310/14
Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.
Abstract translation: 通过开环聚合制备的聚合物，其包含可用于递送核酸如miRNA或siRNA的组合物中的氨基。 在一些实施方案中，本文还提供了包含本文所述的聚合物和核酸的组合物。 在一些实施方案中，这些组合物用于在体内沉默一种或多种基因或治疗疾病或病症。
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