公开(公告)号：US11999683B2

公开(公告)日：2024-06-04

申请号：US18335960

申请日：2023-06-15

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. Siegwart ,  Kejin Zhou

IPC: C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

公开(公告)号：US09801944B2

公开(公告)日：2017-10-31

申请号：US15261245

申请日：2016-09-09

Applicant: The Board of Regents of the University of Texas System

Inventor： Daniel J. Siegwart ,  Jing Hao ,  Kejin Zhou ,  Jason Miller ,  Petra Kos ,  Lian Xue

IPC: A61K47/34 ,  C07H21/02 ,  C07H21/04 ,  A61K47/28 ,  A61K47/22 ,  C08G65/48 ,  C08G63/91 ,  A61K31/713 ,  A61K9/00 ,  A61K47/24 ,  C08G63/688 ,  C12N15/113 ,  A61K9/51

CPC classification number: A61K47/34 ,  A61K9/0019 ,  A61K9/5153 ,  A61K31/713 ,  A61K47/22 ,  A61K47/24 ,  A61K47/28 ,  C08G63/688 ,  C08G63/912 ,  C08G65/48 ,  C12N15/113 ,  C12N2310/14

Abstract: Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments, these compositions are used to silence one or more genes in vivo or treat a disease or disorder.

公开(公告)号：US09751970B2

公开(公告)日：2017-09-05

申请号：US15072522

申请日：2016-03-17

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K8/00 ,  C08F293/00 ,  C07D311/92 ,  A61K9/127 ,  A61K47/48 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K31/352 ,  A61K9/107 ,  A61K49/00 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US11447593B2

公开(公告)日：2022-09-20

申请号：US16814845

申请日：2020-03-10

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K49/00 ,  C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US11098150B2

公开(公告)日：2021-08-24

申请号：US16006885

申请日：2018-06-13

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: A61K49/00 ,  C08F293/00 ,  C07D311/92 ,  A61K47/58 ,  A61K47/62 ,  A61K9/127 ,  A61K31/352 ,  A61P35/00 ,  C08F299/02 ,  A61K47/69 ,  C08G81/02 ,  G01N33/58 ,  A61K9/50 ,  A61K31/337 ,  A61K31/704 ,  A61K9/107 ,  A61K47/68 ,  C08F220/34

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US12091486B2

公开(公告)日：2024-09-17

申请号：US17810591

申请日：2022-07-01

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: C08F293/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/50 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69 ,  A61K49/00 ,  A61P35/00 ,  C07D311/92 ,  C08F299/02 ,  C08G81/02 ,  G01N33/58

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K47/6907 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61P35/00 ,  C07D311/92 ,  C08F299/024 ,  C08G81/025 ,  G01N33/582 ,  A61K49/005 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises




wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US11858884B2

公开(公告)日：2024-01-02

申请号：US17566666

申请日：2021-12-30

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. Siegwart ,  Kejin Zhou

IPC: C07C321/14 ,  A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C323/52 ,  C07D295/15 ,  A61K47/20 ,  A61K47/22

CPC classification number: C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

Abstract: Disclosed herein are methods for modulating an amount or activity of a gene or a gene product in a cell. The methods herein may comprise contacting a cell with a therapeutic agent assembled with a lipid composition, which lipid composition may comprise a dendrimer or dendron which may comprise one or more degradable diacyl group, in which may result in modulating the amount or activity of the gene or the gene product in the cell. The therapeutic agent modulating a gene or gene product in a cell may be sufficient to treat a disease or disorder in a subject. Further disclosed herein are pharmaceutical compositions, kits, and lipid compositions for modulating an amount or activity of a gene or a gene product in a cell.

公开(公告)号：US09872926B2

公开(公告)日：2018-01-23

申请号：US15297862

申请日：2016-10-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Kejin Zhou ,  Baran D. Sumer

IPC: A61K9/00 ,  A61K49/00 ,  G01N21/64 ,  G01N33/50

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

公开(公告)号：US09511152B2

公开(公告)日：2016-12-06

申请号：US13827197

申请日：2013-03-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Kejin Zhou ,  Baran D. Sumer

IPC: A61K9/14 ,  A61K49/00 ,  G01N21/64

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。

公开(公告)号：US12024486B2

公开(公告)日：2024-07-02

申请号：US18335974

申请日：2023-06-15

Applicant: The Board of Regents of The University of Texas System

Inventor： Daniel J. Siegwart ,  Kejin Zhou

IPC: A61K9/51 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/69 ,  A61K48/00 ,  C07C321/14 ,  C07C323/52 ,  C07D295/15

CPC classification number: C07C321/14 ,  A61K9/513 ,  A61K9/5146 ,  A61K31/7105 ,  A61K31/7125 ,  A61K47/20 ,  A61K47/22 ,  A61K47/59 ,  A61K47/60 ,  A61K47/6931 ,  A61K48/0041 ,  C07C323/52 ,  C07D295/15

Abstract: Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.