公开(公告)号：US11890320B2

公开(公告)日：2024-02-06

申请号：US16864872

申请日：2020-05-01

Applicant: The Board of Regents of the University of Texas System

Inventor： Sean Morrison ,  Rui Yue

IPC: A61K38/18 ,  A61P19/08 ,  A61K38/29 ,  A61K45/06 ,  A61P35/04 ,  A61P19/10

CPC classification number: A61K38/18 ,  A61K38/29 ,  A61K45/06 ,  A61P19/08 ,  A61P19/10 ,  A61P35/04 ,  A61K38/29 ,  A61K2300/00

Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.

公开(公告)号：US11285190B2

公开(公告)日：2022-03-29

申请号：US15567762

申请日：2016-04-18

Applicant: The Board of Regents of the University of Texas System

Inventor： Sean Morrison ,  Rui Yue

IPC: A61K38/18 ,  A61P19/08 ,  A61K38/29 ,  A61K45/06 ,  A61P35/04 ,  A61P19/10

Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.

公开(公告)号：US20200297816A1

公开(公告)日：2020-09-24

申请号：US16864872

申请日：2020-05-01

Applicant: The Board of Regents of the University of Texas System

Inventor： Sean Morrison ,  Rui Yue

IPC: A61K38/18 ,  A61K38/29 ,  A61K45/06 ,  A61P19/08 ,  A61P35/04 ,  A61P19/10

Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.