公开(公告)号：US20180207107A1

公开(公告)日：2018-07-26

申请号：US15742842

申请日：2016-07-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Connie HSIA ,  Yi HONG ,  Orson W. MOE ,  Kytai NGUYEN

IPC: A61K9/51 ,  A61K9/00 ,  A61P11/00 ,  A61K38/47 ,  A61K31/713

CPC classification number: A61K9/5176 ,  A61K9/0019 ,  A61K9/0078 ,  A61K9/5153 ,  A61K31/713 ,  A61K38/47 ,  A61P11/00 ,  C12Y302/01031

Abstract: Nanoparticles coated with extracellular matrix (ECM) are provided, in some aspects, for the delivery of a therapeutic protein, nucleic acid, or drug. In some embodiments, the nanoparticles are delivered to a subject via inhalation or aerosol delivery. Also provided, in some aspects, are methods for treating acute lung injury comprising administering α-Klotho (αKlotho) protein or DNA to a subject.