公开(公告)号：US20180353622A1

公开(公告)日：2018-12-13

申请号：US16003683

申请日：2018-06-08

Applicant: The Board of Regents of the University of Texas System

Inventor： Lawrence LUM ,  Rubina TULADHAR ,  Tae Hyun HWANG ,  Yunku YEU ,  John Tyler PIAZZA ,  Quinn BARRETT

IPC: A61K48/00 ,  A61K38/46 ,  C12N15/11

CPC classification number: A61K48/0066 ,  A61K38/465 ,  C12N15/11 ,  C12N2310/20

Abstract: Disclosed herein are methods for gene inactivation or rescue by cutting genomic DNA at regions of putative exon splicing enhancers with CRISPR-type enzymes.