公开(公告)号：US20210024924A1

公开(公告)日：2021-01-28

申请号：US16809343

申请日：2020-03-04

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Intima Bioscience, Inc.

发明人： Lei S. Qi ,  Modassir S. Choudhry ,  Xueqiu Lin ,  Xiaoshu Xu

IPC分类号： C12N15/113

摘要： Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.

公开(公告)号：US20220089659A1

公开(公告)日：2022-03-24

申请号：US17464635

申请日：2021-09-01

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Intima Bioscience, Inc.

发明人： Lei S. Qi ,  Modassir Choudhry ,  Xueqiu Lin ,  Trevor N. Collingwood ,  Thomas Henley ,  Benjamin Klapholz ,  Tilmann Buerckstuemmer ,  Sejla Salic

IPC分类号： C07K14/33 ,  C12N15/11 ,  C12N9/22 ,  A61K38/46 ,  A61K38/16 ,  A61K31/7088 ,  C12N9/14

摘要： Constructs comprising Argonautes and neighboring genes are disclosed for use in gene editing. Disclosed are also compositions and methods utilizing these Argonautes and neighboring genes. Also disclosed are the methods of making and using the Argonautes and neighboring genes in treating various diseases, conditions, and cancer.

公开(公告)号：US20230235324A1

公开(公告)日：2023-07-27

申请号：US17871848

申请日：2022-07-22

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Intima Bioscience, Inc.

发明人： LEI S QI ,  Modassir S. Choudhry ,  Xueqiu Lin ,  Xiaoshu Xu

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N2310/321 ,  C12N2310/322

摘要： Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.

公开(公告)号：US11447774B2

公开(公告)日：2022-09-20

申请号：US16809343

申请日：2020-03-04

申请人： The Board of Trustees of the Leland Stanford Junior University ,  Intima Bioscience, Inc.

发明人： Lei S. Qi ,  Modassir S. Choudhry ,  Xueqiu Lin ,  Xiaoshu Xu

IPC分类号： C07H21/04 ,  C07H21/02 ,  C12N15/113

摘要： Fusion constructs encoding RNase-H-like domain containing compositions are disclosed. Disclosed are also compositions and methods utilizing RNase-H-like domain containing compositions for the treatment of cancer. Also disclosed are the methods of making and using the RNase-H-like domain containing compositions in treating various diseases, conditions, and cancer.