公开(公告)号：US20230381137A1

公开(公告)日：2023-11-30

申请号：US18364621

申请日：2023-08-03

申请人： The Board of Trustees of the University of Illinois

发明人： Gregory R THATCHER ,  Rui XIONG ,  Jiong ZHAO ,  Yunlong LU ,  Lauren GUTGESELL ,  Carlo Ivan ROSALES ,  Yangfeng LI

IPC分类号： A61K31/397 ,  A61K31/138 ,  A61K31/167 ,  A61K31/277 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/566 ,  A61K31/573 ,  A61K38/09 ,  A61K39/395 ,  A61K45/06 ,  C07D409/12

CPC分类号： A61K31/397 ,  A61K31/138 ,  A61K31/167 ,  A61K31/277 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/4535 ,  A61K31/565 ,  A61K31/566 ,  A61K31/573 ,  A61K38/09 ,  A61K39/3955 ,  A61K45/06 ,  C07D409/12 ,  C07B2200/05

摘要： In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.