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公开(公告)号：US20240293412A1
公开(公告)日：2024-09-05
申请号：US18553909
申请日：2022-04-07
申请人： The Board of Trustees of the University of Illinois , ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： Gregory R THATCHER , Rui XIONG , Kiira RATIA , Yangfeng LI , Zhengnan SHEN
IPC分类号： A61K31/519 , A61K31/55 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00
CPC分类号： A61K31/519 , A61K31/55 , C07D487/04 , C07D491/048 , C07D495/04 , C07D519/00
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds and methods for activating NAMPT in a subject. The compounds described herein are useful in treating a neurological disorder, disease, or condition. In another aspect, compounds described herein are useful in treating metabolic disorders and diabetes. Formula (I)
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公开(公告)号：US20230381137A1
公开(公告)日：2023-11-30
申请号：US18364621
申请日：2023-08-03
发明人： Gregory R THATCHER , Rui XIONG , Jiong ZHAO , Yunlong LU , Lauren GUTGESELL , Carlo Ivan ROSALES , Yangfeng LI
IPC分类号： A61K31/397 , A61K31/138 , A61K31/167 , A61K31/277 , A61K31/4025 , A61K31/4196 , A61K31/4535 , A61K31/565 , A61K31/566 , A61K31/573 , A61K38/09 , A61K39/395 , A61K45/06 , C07D409/12
CPC分类号： A61K31/397 , A61K31/138 , A61K31/167 , A61K31/277 , A61K31/4025 , A61K31/4196 , A61K31/4535 , A61K31/565 , A61K31/566 , A61K31/573 , A61K38/09 , A61K39/3955 , A61K45/06 , C07D409/12 , C07B2200/05
摘要： In one aspect, the disclosure relates to relates to substituted benzothiophene analogs which are useful as selective degraders of estrogen receptor, methods of making same, pharmaceutical compositions comprising same, and methods of treating one or more clinical conditions associated with estrogen receptor, such as a cancer, including breast cancer, or osteoporosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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