公开(公告)号：US11672864B2

公开(公告)日：2023-06-13

申请号：US16895638

申请日：2020-06-08

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K9/00 ,  A61K9/06 ,  A61K9/107 ,  A61K31/166 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/58 ,  A61K31/573 ,  A61K47/26 ,  A61K47/28 ,  A61K47/14 ,  A61K31/713 ,  A61K38/28

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/166 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

公开(公告)号：US09974859B2

公开(公告)日：2018-05-22

申请号：US15174267

申请日：2016-06-06

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K38/28 ,  A61K31/4188 ,  A61K31/405 ,  A61K31/713 ,  A61K31/4745 ,  A61K31/58 ,  A61K9/107 ,  A61K47/14 ,  A61K9/06 ,  A61K47/26 ,  A61K31/573 ,  A61K47/28 ,  A61K9/00 ,  A61K31/166

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/166 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

公开(公告)号：US20230346946A1

公开(公告)日：2023-11-02

申请号：US18310311

申请日：2023-05-01

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K9/00 ,  A61K9/06 ,  A61K31/166 ,  A61K31/573 ,  A61K47/26 ,  A61K47/28 ,  A61K9/107 ,  A61K47/14 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/06 ,  A61K31/166 ,  A61K31/573 ,  A61K47/26 ,  A61K47/28 ,  A61K9/1075 ,  A61K47/14 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

公开(公告)号：US10675351B2

公开(公告)日：2020-06-09

申请号：US15971925

申请日：2018-05-04

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K31/58 ,  A61K9/00 ,  A61K31/405 ,  A61K31/4745 ,  A61K38/28 ,  A61K9/06 ,  A61K31/166 ,  A61K31/573 ,  A61K47/26 ,  A61K47/28 ,  A61K9/107 ,  A61K47/14 ,  A61K31/4188 ,  A61K31/713

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

公开(公告)号：US20180318423A1

公开(公告)日：2018-11-08

申请号：US15971925

申请日：2018-05-04

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K31/58 ,  A61K9/00 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K38/28 ,  A61K9/107 ,  A61K47/14 ,  A61K47/28 ,  A61K47/26 ,  A61K31/573 ,  A61K31/166 ,  A61K9/06 ,  A61K31/713

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

公开(公告)号：US20210008213A1

公开(公告)日：2021-01-14

申请号：US16895638

申请日：2020-06-08

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K9/00 ,  A61K9/06 ,  A61K31/166 ,  A61K31/573 ,  A61K47/26 ,  A61K47/28 ,  A61K9/107 ,  A61K47/14 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

公开(公告)号：US20170000888A1

公开(公告)日：2017-01-05

申请号：US15174267

申请日：2016-06-06

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： Jeffrey M. Karp ,  Praveen Kumar Vemula ,  Nathaniel R. Campbell ,  Abdullah M. Syed ,  Sufeng Zhang ,  Omid C. Farokhzad ,  Robert S. Langer

IPC分类号： A61K47/22 ,  A61K31/4188 ,  A61K31/4745 ,  A61K38/28 ,  A61K31/573 ,  A61K31/405 ,  A61K31/713 ,  A61K47/26 ,  A61K31/58

CPC分类号： A61K47/22 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/1075 ,  A61K31/166 ,  A61K31/405 ,  A61K31/4188 ,  A61K31/4745 ,  A61K31/573 ,  A61K31/58 ,  A61K31/713 ,  A61K38/28 ,  A61K47/14 ,  A61K47/26 ,  A61K47/28

摘要： Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also described.

摘要翻译： 描述了包含胶凝剂，例如分子量为2500以下的可酶切割凝胶剂的自组装凝胶组合物。 自组装凝胶组合物可以包封一种或多种试剂。 还描述了使用自组装凝胶组合物制备自组装凝胶组合物的方法和药物递送方法。