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公开(公告)号：US11634773B2
公开(公告)日：2023-04-25
申请号：US16628067
申请日：2018-07-13
申请人： THE FRANCIS CRICK INSTITUTE LIMITED , UNIVERSITY COLLEGE LONDON , CANCER RESEARCH TECHNOLOGY LIMITED
IPC分类号： C12Q1/6881 , C12Q1/6869 , A61K39/00 , C12Q1/6886 , C07K14/74 , C07K16/28
摘要： The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
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公开(公告)号：US20210147942A1
公开(公告)日：2021-05-20
申请号：US16628070
申请日：2018-07-04
IPC分类号： C12Q1/6886 , A61K35/17 , C07K16/28
摘要： The present invention relates to a method for identifying a subject with cancer who is suitable for treatment with an immune checkpoint intervention, said method comprising analysing in a sample isolated from said subject the expressed frameshift indel mutational burden.
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公开(公告)号：US20210147934A1
公开(公告)日：2021-05-20
申请号：US16628067
申请日：2018-07-13
申请人： THE FRANCIS CRICK INSTITUTE LIMITED , UNIVERSITY COLLEGE LONDON , CANCER RESEARCH TECHNOLOGY LIMITED
IPC分类号： C12Q1/6881 , C12Q1/6886 , A61K39/00 , C12Q1/6869
摘要： The present invention relates to a method for determining whether an HLA allele is lost in a tumour in a subject, wherein said method comprises the step of determining the specific copy number of said HLA allele in said tumour. The invention also relates to a method for treating cancer in a subject, comprising targeting a neoantigen which is predicted to be presented by an HLA molecule encoded by an HLA allele which has been determined not to have been lost in a tumour in said subject.
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