公开(公告)号：US20160068503A1

公开(公告)日：2016-03-10

申请号：US14854919

申请日：2015-09-15

申请人： The Hong Kong Polytechnic University ,  Wayne State University ,  University of South Florida ,  McGill University

发明人： Tak-Hang CHAN ,  Wai-Har LAM ,  Larry Ming-Cheung CHOW ,  Qing Ping DOU ,  Deborah Joyce KUHN ,  Aslamuzzaman KAZI ,  Sheng Biao WAN ,  Kristin R. LANDIS-PIWOWAR

IPC分类号： C07D311/62

CPC分类号： C07D311/62 ,  Y02P20/582

摘要： A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:

摘要翻译： 一种减少肿瘤细胞生长的方法，所述方法包括施用有效量的具有下式的化合物：

公开(公告)号：US20170291887A1

公开(公告)日：2017-10-12

申请号：US15279686

申请日：2016-09-29

申请人： The Hong Kong Polytechnic University ,  The Royal Institution for the Advancement of Learning / McGill University

发明人： Kwok-yin WONG ,  Tak-Hang CHAN ,  Kin-Fai CHAN

IPC分类号： C07D401/04

CPC分类号： C07D401/04

摘要： Filamenting temperature-sensitive mutant Z (FtsZ) protein plays a crucial role in the bacterial cell division machinery and is a validated drug target for antibacterial agents. The present invention relates to FtsZ-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine scaffold. Some of these compounds possess potent anti-staphylococcal properties and potent antibacterial activities against clinically isolated MRSA strains. Compounds have been identified to exhibit low spontaneous frequency of resistance, low toxicity as well as the ability to rescue G. mellonella larvae infected with lethal dose of the MRSA ATCC 43300 strain. Characterization by saturation transfer difference NMR, light scattering assay and GTPase hydrolysis assay with purified S. aureus FtsZ protein verified the interaction of 2,4,6-trisubstituted pyrimidine with the FtsZ protein, further confirmed by observations of iconic filamentous cell phenotype and mislocalization of the Z-ring formation. Taken together, these pyrimidine derivatives have the potential as effective treatment of staphylococcal infections.

公开(公告)号：US20190151282A1

公开(公告)日：2019-05-23

申请号：US16259620

申请日：2019-01-28

申请人： The Hong Kong Polytechnic University ,  The Chinese University of Hong Kong

发明人： Tak-Hang CHAN ,  Chi-Chiu WANG

IPC分类号： A61K31/353 ,  A61K9/00

摘要： Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(−)-EGCG]. Use of PRO-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.

公开(公告)号：US20200261408A1

公开(公告)日：2020-08-20

申请号：US16865435

申请日：2020-05-04

申请人： The Hong Kong Polytechnic University ,  The Chinese University of Hong Kong

发明人： Tak-Hang CHAN ,  Chi-Chiu WANG

IPC分类号： A61K31/353 ,  A61K9/00

摘要： Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(−)-EGCG]. Use of PRO-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.