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    EXTRACTION METHOD OF PROANTHOCYANIDIN FROM CHINESE BAYBERRY (MYRICA RUBRA SIEB. ET ZUCC) LEAVES
    1.
    发明申请
    EXTRACTION METHOD OF PROANTHOCYANIDIN FROM CHINESE BAYBERRY (MYRICA RUBRA SIEB. ET ZUCC) LEAVES 有权

    公开(公告)号：US20220324827A1

    公开(公告)日：2022-10-13

    申请号：US17765359

    申请日：2020-08-25

    申请人： ZHEJIANG UNIVERSITY

    发明人： Shiguo CHEN ,  Haibo PAN ,  Wenyang TAO ,  Xingqian YE

    IPC分类号： C07D311/62 ,  B01D11/02 ,  B01D21/26

    摘要： An extraction method of proanthocyanidins from Myrica rubra Sieb. Et Zucc leaves is provided. In the method, proanthocyanidins from Myrica rubra Sieb. Et Zucc leaf are obtained by preparing an aqueous Myrica rubra Sieb. Et Zucc leaf suspension and centrifuging. In the method, only water is used as an extraction reagent without introduction of an organic extraction solvent, which reduces costs and is free from environmental pollution; moreover, the method does not cause organic reagent residue in a product, such that the biological activity of the proanthocyanidins is not affected and product safety is improved without affecting product quality; meanwhile, extraction steps are simplified, extraction time is reduced and extraction efficiency is improved. The method provides stability, good reproducibility, simple equipment and easy control of conditions.

    Process for the separation of gallated epicatechins (EGCG and ECG) from green tea extract or green tea dust
    2.
    发明授权
    Process for the separation of gallated epicatechins (EGCG and ECG) from green tea extract or green tea dust 有权

    公开(公告)号：US11420954B2

    公开(公告)日：2022-08-23

    申请号：US16769853

    申请日：2018-11-26

    申请人： CRYSTALMORPHIX TECHNOLOGIES PVT. LTD

    发明人： Vamsee Krishna Muppidi ,  Satyanarayana Chinta

    IPC分类号： C07D311/62 ,  A61K31/353 ,  A61K36/82

    摘要： The present invention relates to an improved process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust. The present invention specifically relates to an improved process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust by forming hydrated gallated epicatechins (EGCG & ECG)-isonicotinic acid complex using isonicotinic acid as acid, organic solvents for liberating gallated epicatechins. The present invention more specifically relates to the process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust, wherein processes comprises steps of dissolving, concentrating by centrifugation, adding, precipitating, filtering, slurrying, removing supernatant liquid, washing, extracting and freeze drying. The present invention also relates to hydrated gallated epicatechins (EGCG & ECG)-isonicotinic acid complex.

    Membrane fusion inhibitor
    5.
    发明授权
    Membrane fusion inhibitor 有权

    公开(公告)号：US09901565B2

    公开(公告)日：2018-02-27

    申请号：US14581543

    申请日：2014-12-23

    申请人： Protectea, Ltd.

    发明人： Kunihiro Kaihatsu ,  Shuichi Mori ,  Tomo Daidoji ,  Nobuo Kato ,  Shinya Miyake

    IPC分类号： A61K31/35 ,  A61K31/22 ,  A61K31/353 ,  A61K45/06 ,  C07D311/62

    CPC分类号： A61K31/353 ,  A61K45/06 ,  A61K2300/00 ,  C07D311/62

    摘要： The present invention provides a pharmaceutical composition that has excellent safety and targets a different step in the virus propagation cycle than conventional pharmaceutical compositions, applicable as an antiviral agent. A pharmaceutical composition containing an epigallocatechin gallate derivative represented by the following chemical formula (1), an isomer thereof, or a salt thereof is prepared. This can be used as a membrane fusion inhibitor that inhibits viral membrane fusion. In the following formula, R1 to R6 are each a hydrogen atom, halogen, sodium, potassium, or a straight-chain or branched, saturated or unsaturated acyl group and may be identical to or different from one another. The acyl group may be substituted further with one or more substituents. At least one of R1 to R6 is the acyl group. R7 to R16 are each a hydrogen atom, halogen, sodium, or potassium and may be identical to or different from one another.

    METHODS AND COMPOSITIONS FOR ATTENUATING ALLERGENICITY IN PROTEIN PRODUCTS
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR ATTENUATING ALLERGENICITY IN PROTEIN PRODUCTS 审中-公开

    公开(公告)号：US20170333386A1

    公开(公告)日：2017-11-23

    申请号：US15524087

    申请日：2015-11-05

    申请人： NORTH CAROLINA STATE UNIVERSITY

    发明人： Mary Ann Lila ,  Mary H. Grace

    IPC分类号： A61K31/35 ,  A23L33/105 ,  C07D311/62 ,  B01D11/02 ,  A61K39/35

    CPC分类号： A61K31/35 ,  A23L33/105 ,  A23V2002/00 ,  A61K39/35 ,  B01D11/02 ,  C07D311/62

    摘要： The invention relates to a low sugar or sugar free concentrated polyphenolic extract comprising at least about 30% polyphenols (w/w) and a protein-polyphenol aggregate matrix comprising at least about 15% polyphenols (w/w). The invention further relates to methods of producing a low sugar or sugar free concentrated polyphenolic extract comprising (a) extracting a low sugar or sugar free plant tissue with an aqueous solvent to produce an extract having an aqueous portion and a solids portion; (b) filtering the extract to separate the aqueous portion from the solids portion; and (c) reducing the volume of the separated aqueous portion, and methods of producing a protein-polyphenol aggregate matrix comprising about 1% to about 40% polyphenols (w/w) using the low sugar or sugar free concentrated polyphenolic extract of the invention.