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公开(公告)号：US11672786B2
公开(公告)日：2023-06-13
申请号：US16325066
申请日：2017-08-12
IPC分类号： A61K31/4375 , A61P25/28 , A61K9/00 , A61K9/127
CPC分类号： A61K31/4375 , A61K9/0019 , A61K9/127 , A61P25/28
摘要： Methods of treating diseases caused by repeat DNA instability are described herein. The methods described herein can inhibit the further expansion of repeat DNA and, in some instances, reduce the size of the repeat DNA (e.g., reduce the number of repeats).
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公开(公告)号：US20210283114A1
公开(公告)日：2021-09-16
申请号：US16325066
申请日：2017-08-12
IPC分类号： A61K31/4375 , A61K9/00 , A61K9/127 , A61P25/28
摘要： Methods of treating diseases caused by repeat DNA instability are described herein. The methods described herein can inhibit the further expansion of repeat DNA and, in some instances, reduce the size of the repeat DNA (e.g., reduce the number of repeats).
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公开(公告)号：US09057105B2
公开(公告)日：2015-06-16
申请号：US14352208
申请日：2013-03-08
发明人： Kazuhiko Nakatani , Fumie Takei , Chikara Dohno , Xi Chen
CPC分类号： C12Q1/6883 , C12Q1/68 , C12Q1/6827 , G01N33/53 , G01N33/542 , C12Q2525/301 , C12Q2527/125 , C12Q2563/107
摘要： A method for detecting a single nucleotide polymorphism in nucleic acids, characterized in that the method includes mixing (A) a nucleic acid probe comprising a nucleotide sequence complementarily hybridizable to an evaluation subject nucleic acid/an antisense strand thereof containing at least one single nucleotide polymorphism, and tagged with a nucleotide sequence of a hairpin structure having a bulge at a 5′-terminal thereof, wherein a guanine residue is introduced at an adjoining position of the bulge, and wherein a naphthyridine derivative compound is immobilized to the bulge; and (B) the evaluation subject nucleic acids; and detecting a signal ascribed to the naphthyridine derivative compound when the above nucleic acid probe and the above evaluation subject nucleic acids are hybridized, thereby evaluating the above single nucleotide polymorphism.
摘要翻译： 一种用于检测核酸单核苷酸多态性的方法，其特征在于该方法包括混合（A）核酸探针，该核酸探针包含与包含至少一个单核苷酸多态性的评估对象核酸/其反义链互补可杂交的核苷酸序列 并用其5'末端具有凸起的发夹结构的核苷酸序列进行标记，其中在凸起的相邻位置引入鸟嘌呤残基，并且其中将萘啶衍生物化合物固定在凸起上; 和（B）评价对象核酸; 并且当上述核酸探针和上述评价对象核酸杂交时，检测归属于萘啶衍生物的信号，从而评价上述单核苷酸多态性。
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公开(公告)号：US20140255938A1
公开(公告)日：2014-09-11
申请号：US14352208
申请日：2013-03-08
发明人： Kazuhiko Nakatani , Fumie Takei , Chikara Dohno , Xi Chen
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/68 , C12Q1/6827 , G01N33/53 , G01N33/542 , C12Q2525/301 , C12Q2527/125 , C12Q2563/107
摘要： A method for detecting a single nucleotide polymorphism in nucleic acids, characterized in that the method includes mixing (A) a nucleic acid probe comprising a nucleotide sequence complementarily hybridizable to an evaluation subject nucleic acid/an antisense strand thereof containing at least one single nucleotide polymorphism, and tagged with a nucleotide sequence of a hairpin structure having a bulge at a 5′-terminal thereof, wherein a guanine residue is introduced at an adjoining position of the bulge, and wherein a naphthyridine derivative compound is immobilized to the bulge; and (B) the evaluation subject nucleic acids; and detecting a signal ascribed to the naphthyridine derivative compound when the above nucleic acid probe and the above evaluation subject nucleic acids are hybridized, thereby evaluating the above single nucleotide polymorphism.
摘要翻译： 一种用于检测核酸单核苷酸多态性的方法，其特征在于该方法包括混合（A）核酸探针，该核酸探针包含与包含至少一个单核苷酸多态性的评估对象核酸/其反义链互补可杂交的核苷酸序列 并用其5'末端具有凸起的发夹结构的核苷酸序列进行标记，其中在凸起的相邻位置引入鸟嘌呤残基，并且其中将萘啶衍生物化合物固定在凸起上; 和（B）评价对象核酸; 并且当上述核酸探针和上述评价对象核酸杂交时，检测归属于萘啶衍生物的信号，从而评价上述单核苷酸多态性。
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