公开(公告)号：US20210275561A1

公开(公告)日：2021-09-09

申请号：US17139665

申请日：2020-12-31

申请人： The Johns Hopkins University

发明人： Franco D'Alessio ,  Benjamin David Singer ,  Landon King ,  Neil Raj Aggarwal

IPC分类号： A61K31/7068 ,  A61K31/502 ,  A61K31/245 ,  A61K31/353 ,  A61K31/706 ,  A61P11/00 ,  A61P29/00 ,  A61P31/16 ,  A61K31/166

摘要： The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an IL-4 polypeptide or fragment thereof possessing cytokine activity or an IL-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. Other exemplary methods involve administering an inhibitor of DNA methylation systemically to a subject and/or administering an inhibitor of DNA methylation to a cell population comprising T cells (e.g., Treg cells) for introduction/re-introduction to a subject having an inflammatory disease or disorder and/or a lung injury. Compositions and cells for use in such methods are also provided.

公开(公告)号：US10905706B2

公开(公告)日：2021-02-02

申请号：US15542380

申请日：2016-01-08

申请人： The Johns Hopkins University

发明人： Franco D'Alessio ,  Benjamin David Singer ,  Landon King ,  Neil Raj Aggarwal

IPC分类号： A61K31/7068 ,  A61P11/00 ,  A61K31/502 ,  A61K31/245 ,  A61K31/353 ,  A61K31/706 ,  A61P29/00 ,  A61P31/16 ,  A61K31/166

摘要： The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an IL-4 polypeptide or fragment thereof possessing cytokine activity or an IL-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. Other exemplary methods involve administering an inhibitor of DNA methylation systemically to a subject and/or administering an inhibitor of DNA methylation to a cell population comprising T cells (e.g., Treg cells) for introduction/re-introduction to a subject having an inflammatory disease or disorder and/or a lung injury. Compositions and cells for use in such methods are also provided.

公开(公告)号：US20180125874A1

公开(公告)日：2018-05-10

申请号：US15542380

申请日：2016-01-08

申请人： The Johns Hopkins University

发明人： Franco D'Alessio ,  Benjamin David Singer ,  Landon King ,  Neil Raj Aggarwal

IPC分类号： A61K31/7068 ,  A61K31/502 ,  A61K31/245 ,  A61K31/166 ,  A61K31/353 ,  A61P29/00 ,  A61P11/00 ,  A61P31/16

CPC分类号： A61K31/7068 ,  A61K31/166 ,  A61K31/245 ,  A61K31/353 ,  A61K31/502 ,  A61K31/706 ,  A61P11/00 ,  A61P29/00 ,  A61P31/16

摘要： The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an IL-4 polypeptide or fragment thereof possessing cytokine activity or an IL-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. Other exemplary methods involve administering an inhibitor of DNA methylation systemically to a subject and/or administering an inhibitor of DNA methylation to a cell population comprising T cells (e.g., Treg cells) for introduction/re-introduction to a subject having an inflammatory disease or disorder and/or a lung injury. Compositions and cells for use in such methods are also provided.