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公开(公告)号：US09417247B2
公开(公告)日：2016-08-16
申请号：US14617412
申请日：2015-02-09
IPC分类号： G01N33/53 , G01N33/68 , G01N33/564
CPC分类号： G01N33/686 , G01N33/564 , G01N2333/978 , G01N2800/102 , G01N2800/12 , G01N2800/52
摘要： In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to PAD3 protein. Methods of diagnosis of subjects for rheumatoid arthritis (RA) using these antibodies as well as diagnosis of the severity of RA in the subject, and methods for monitoring treatment of a subject with RA are also provided. The biomarkers provided herein are also useful in the diagnosis of connective tissue-interstitial lung disease (CT-ILD) in patients having or suspected of having RA.
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2.发明申请HUMAN AUTOANTIBODIES SPECIFIC FOR PAD3 WHICH ARE CROSS-REACTIVE WITH PAD4 AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED DISEASES 有权PAD4与PAD4交叉反应的人体免疫球蛋白特异性及其在诊断和治疗恶病质和相关疾病中的应用公开(公告)号：US20150198609A1
公开(公告)日：2015-07-16
申请号：US14617412
申请日：2015-02-09
IPC分类号： G01N33/68
CPC分类号： G01N33/686 , G01N33/564 , G01N2333/978 , G01N2800/102 , G01N2800/12 , G01N2800/52
摘要： In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to PAD3 protein. Methods of diagnosis of subjects for rheumatoid arthritis (RA) using these antibodies as well as diagnosis of the severity of RA in the subject, and methods for monitoring treatment of a subject with RA are also provided. The biomarkers provided herein are also useful in the diagnosis of connective tissue-interstitial lung disease (CT-ILD) in patients having or suspected of having RA.
摘要翻译： 在一个或多个实施方案中，本发明提供了一种新的生物标志物，其提供不同临床表型与自身抗体对涉及疾病发病机理的酶的生物化学作用之间的联系。 特别地，本发明提供了PAD3蛋白的分离或纯化的人自身抗体。 还提供了使用这些抗体诊断类风湿性关节炎（RA）的受试者的方法以及受试者中RA的严重程度的诊断，以及用RA监测受试者的治疗方法。 本文提供的生物标志物也可用于诊断具有或怀疑具有RA的患者的结缔组织间质性肺病（CT-ILD）。
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3.发明授权Human autoantibodies specific for PAD3 which are cross-reactive with PAD4 and their use in the diagnosis and treatment of rheumatoid arthritis and related diseases 有权与PAD4交叉反应的PAD3特异性的人类自身抗体及其在类风湿性关节炎和相关疾病的诊断和治疗中的应用公开(公告)号：US08975033B2
公开(公告)日：2015-03-10
申请号：US14071996
申请日：2013-11-05
IPC分类号： G01N33/53 , G01N33/564
CPC分类号： G01N33/686 , G01N33/564 , G01N2333/978 , G01N2800/102 , G01N2800/12 , G01N2800/52
摘要： In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to PAD3 protein. Methods of diagnosis of subjects for rheumatoid arthritis (RA) using these antibodies as well as diagnosis of the severity of RA in the subject, and methods for monitoring treatment of a subject with RA are also provided. The biomarkers provided herein are also useful in the diagnosis of connective tissue-interstitial lung disease (CT-ILD) in patients having or suspected of having RA.
摘要翻译： 在一个或多个实施方案中，本发明提供了一种新的生物标志物，其提供不同临床表型与自身抗体对涉及疾病发病机理的酶的生物化学作用之间的联系。 特别地，本发明提供了PAD3蛋白的分离或纯化的人自身抗体。 还提供了使用这些抗体诊断类风湿性关节炎（RA）的受试者的方法以及受试者中RA的严重程度的诊断，以及用RA监测受试者的治疗方法。 本文提供的生物标志物也可用于诊断具有或怀疑具有RA的患者的结缔组织间质性肺病（CT-ILD）。
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4.发明申请HUMAN AUTOANTIBODIES SPECIFIC FOR PAD3 WHICH ARE CROSS-REACTIVE WITH PAD4 AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF RHEUMATOID ARTHRITIS AND RELATED DISEASES 有权PAD4与PAD4交叉反应的人体免疫球蛋白特异性及其在诊断和治疗恶病质和相关疾病中的应用公开(公告)号：US20140127720A1
公开(公告)日：2014-05-08
申请号：US14071996
申请日：2013-11-05
IPC分类号： G01N33/68
CPC分类号： G01N33/686 , G01N33/564 , G01N2333/978 , G01N2800/102 , G01N2800/12 , G01N2800/52
摘要： In one or more embodiments, the present invention provides a novel biomarker which provides a link between a distinct clinical phenotype and a biochemical effect of an autoantibody on an enzyme implicated in disease pathogenesis. In particular, the present invention provides an isolated or purified human autoantibody to PAD3 protein. Methods of diagnosis of subjects for rheumatoid arthritis (RA) using these antibodies as well as diagnosis of the severity of RA in the subject, and methods for monitoring treatment of a subject with RA are also provided. The biomarkers provided herein are also useful in the diagnosis of connective tissue-interstitial lung disease (CT-ILD) in patients having or suspected of having RA.
摘要翻译： 在一个或多个实施方案中，本发明提供了一种新的生物标志物，其提供不同临床表型与自身抗体对涉及疾病发病机理的酶的生物化学作用之间的联系。 特别地，本发明提供了PAD3蛋白的分离或纯化的人自身抗体。 还提供了使用这些抗体诊断类风湿性关节炎（RA）的受试者的方法以及受试者中RA的严重程度的诊断，以及用RA监测受试者的治疗方法。 本文提供的生物标志物也可用于诊断具有或怀疑具有RA的患者的结缔组织间质性肺病（CT-ILD）。
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