公开(公告)号：US20240294648A1

公开(公告)日：2024-09-05

申请号：US18473695

申请日：2023-09-25

申请人： The Johns Hopkins University

发明人： Emily Han-Chung Hsiue ,  Qing Wang ,  Bert Vogelstein ,  Kenneth W. Kinzler ,  Shibin Zhou ,  Jacqueline Douglass ,  Michael S. Hwang ,  Nickolas Papadopoulos

IPC分类号： C07K16/28 ,  A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C07K14/73

CPC分类号： C07K16/2833 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/2809 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2319/03

摘要： This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

公开(公告)号：US20210063401A1

公开(公告)日：2021-03-04

申请号：US16765343

申请日：2018-11-20

申请人： The Johns Hopkins University

发明人： Bert Vogelstein ,  Kenneth W. Kinzler ,  Qing Wang ,  Nickolas Papadopoulos ,  Ming Zhang

IPC分类号： G01N33/574

摘要： This document provides methods and materials for identifying biomarkers (e.g., peptide biomarkers) that can be used to identify a mammal as having a disease (e.g., cancer). This document also provides methods and materials for identifying and/or treating cancer. For example, this document provides methods and materials for using one or more peptide fragments derived from a peptidyl-prolyl cis-trans isomerase A (PPIA) polypeptide to identify a mammal as having cancer (e.g., ovarian cancer).

公开(公告)号：US20240345093A1

公开(公告)日：2024-10-17

申请号：US18506393

申请日：2023-11-10

申请人： The Johns Hopkins University

发明人： Bert Vogelstein ,  Kenneth W. Kinzler ,  Qing Wang ,  Nickolas Papadopoulos ,  Ming Zhang

IPC分类号： G01N33/574

CPC分类号： G01N33/57449 ,  G01N2333/99

摘要： This document provides methods and materials for identifying biomarkers (e.g., peptide biomarkers) that can be used to identify a mammal as having a disease (e.g., cancer). This document also provides methods and materials for identifying and/or treating cancer. For example, this document provides methods and materials for using one or more peptide fragments derived from a peptidyl-prolyl cis-trans isomerase A (PPIA) polypeptide to identify a mammal as having cancer (e.g., ovarian cancer).

公开(公告)号：US20200079854A1

公开(公告)日：2020-03-12

申请号：US16614005

申请日：2018-05-16

申请人： The Johns Hopkins University

发明人： Emily Han-Chung Hsiue ,  Qing Wang ,  Bert Vogelstein ,  Kenneth W. Kinzler ,  Shibin Zhou ,  Jacqueline Douglass ,  Michael S. Hwang ,  Nickolas Papadopoulos

IPC分类号： C07K16/28 ,  A61K35/17 ,  C07K14/73 ,  C07K14/705 ,  C07K14/725

摘要： This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.

公开(公告)号：US11807662B2

公开(公告)日：2023-11-07

申请号：US16614005

申请日：2018-05-16

申请人： The Johns Hopkins University

发明人： Emily Han-Chung Hsiue ,  Qing Wang ,  Bert Vogelstein ,  Kenneth W. Kinzler ,  Shibin Zhou ,  Jacqueline Douglass ,  Michael S. Hwang ,  Nickolas Papadopoulos

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C07K14/73 ,  C07K14/705 ,  A61K38/00

CPC分类号： C07K16/2833 ,  A61K35/17 ,  C07K14/7051 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C07K16/2809 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2319/03

摘要： This document provides methods and materials for assessing a mammal having or suspected of having cancer and/or for treating a mammal having cancer. For example, molecules including one or more antigen-binding domains (e.g., a single-chain variable fragment (scFv)) that can bind to a modified peptide (e.g., a tumor antigen), as well as method for using such molecules, are provided.