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公开(公告)号：US20220135529A1
公开(公告)日：2022-05-05
申请号：US17575235
申请日：2022-01-13
发明人： Sangeeta Ray , Martin G. Pomper , Thomas J. Meade , Ronnie C. Mease , Ying Chen , Xing Yang , Matthew Rotz
IPC分类号： C07D257/02 , A61K49/10 , A61K51/04 , C07D403/14 , A61K49/12 , A61K51/06 , A61K49/00
摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
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公开(公告)号：US10683272B2
公开(公告)日：2020-06-16
申请号：US15309009
申请日：2015-05-06
发明人： Sangeeta Ray , Martin G. Pomper , Thomas J. Meade , Ronnie C. Mease , Ying Chen , Xing Yang , Matthew Rotz
IPC分类号： A61K51/00 , A61M36/14 , C07D257/02 , A61K49/10 , A61K51/04 , C07D403/14 , A61K49/12 , A61K51/06 , A61K49/00
摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
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公开(公告)号：US20200290982A1
公开(公告)日：2020-09-17
申请号：US16887754
申请日：2020-05-29
发明人： Sangeeta Ray , Martin G. Pomper , Thomas J. Meade , Ronnie C. Mease , Ying Chen , Xing Yang , Matthew Rotz
IPC分类号： C07D257/02 , A61K49/10 , A61K51/04 , C07D403/14 , A61K49/12 , A61K51/06 , A61K49/00
摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.
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公开(公告)号：US20210030896A1
公开(公告)日：2021-02-04
申请号：US16943820
申请日：2020-07-30
发明人： Thomas J. Meade , Sarah G. Kamper , Michael A. Caldwell , Laura M. Lilley , Hao Li , Ana Rita Batista , Toloo Taghian , Heather L. Gray-Edwards , Miguel Sena-Esteves , Douglas R. Martin
IPC分类号： A61K49/08
摘要： Provided herein are MRI contrast agents that are conditionally activated by an enzyme from a reporter gene coupled to a gene of interest. In some embodiments, provided herein is a platform where a substrate (blocking access of water to a Gd(III) ion) is removed by an enzyme that can be changed to accommodate a number of gene therapy targets.
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公开(公告)号：US20190321492A1
公开(公告)日：2019-10-24
申请号：US16504021
申请日：2019-07-05
摘要： Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
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公开(公告)号：US20170074859A1
公开(公告)日：2017-03-16
申请号：US15251681
申请日：2016-08-30
发明人： Mark C. Hersam , Thomas J. Meade , Hsiang-Hua Hung
CPC分类号： A61K49/105 , A61K47/547 , A61K47/6923 , A61K49/108 , B82Y5/00 , Y10S977/906
摘要： Unmodified graphene oxide conjugated with hydrophilic small molecules for cellular delivery.
摘要翻译： 与亲水小分子结合的未改性石墨烯氧化物用于细胞递送。
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公开(公告)号：US10786582B2
公开(公告)日：2020-09-29
申请号：US16504021
申请日：2019-07-05
摘要： Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
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公开(公告)号：US20160375154A1
公开(公告)日：2016-12-29
申请号：US15192377
申请日：2016-06-24
CPC分类号： A61K49/085 , A61K49/1878
摘要： Provided herein are compositions Gd(III)-dithiolane gold nanoparticle conjugates and methods of use thereof. In particular, compositions and method find use in in vivo imaging (e.g., magnetic resonance imaging (MRI)), for example, of pancreatic tissue.
摘要翻译： 本文提供了组合物Gd（III） - 二硫杂环戊烷金纳米颗粒共轭物及其使用方法。 特别地，组合物和方法可用于例如胰腺组织的体内成像（例如磁共振成像（MRI））。
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公开(公告)号：US10994016B2
公开(公告)日：2021-05-04
申请号：US15251681
申请日：2016-08-30
发明人： Mark C. Hersam , Thomas J. Meade , Hsiang-Hua Hung
摘要： A method of bioactive molecule delivery includes providing a first aqueous medium comprising native graphene oxide and a second aqueous medium comprising a bioactive molecular component that includes Gd(III)-labeled molecules; mixing said first and second media to form a mixture thereof; co-incubating the mixture for a first period of time for coupling said molecular component on a surface of said native graphene oxide, to provide a co-incubation product; and contacting a cellular medium with said co-incubation product for a second period of time for cellular delivery of said bioactive molecular component.
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公开(公告)号：US10656229B2
公开(公告)日：2020-05-19
申请号：US15479821
申请日：2017-04-05
发明人： Thomas J. Meade , Hsiang-Hua Hung
摘要： Provided herein is technology relating to magnetic resonance imaging contrast agents and particularly, but not exclusively, to methods and systems for visualizing one or more magnetic resonance imaging contrast agent.
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