公开(公告)号：US20220135529A1

公开(公告)日：2022-05-05

申请号：US17575235

申请日：2022-01-13

申请人： The Johns Hopkins University ,  Northwestern University

发明人： Sangeeta Ray ,  Martin G. Pomper ,  Thomas J. Meade ,  Ronnie C. Mease ,  Ying Chen ,  Xing Yang ,  Matthew Rotz

IPC分类号： C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14 ,  A61K49/12 ,  A61K51/06 ,  A61K49/00

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US10683272B2

公开(公告)日：2020-06-16

申请号：US15309009

申请日：2015-05-06

申请人： THE JOHNS HOPKINS UNIVERSITY ,  NORTHWESTERN UNIVERSITY

发明人： Sangeeta Ray ,  Martin G. Pomper ,  Thomas J. Meade ,  Ronnie C. Mease ,  Ying Chen ,  Xing Yang ,  Matthew Rotz

IPC分类号： A61K51/00 ,  A61M36/14 ,  C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14 ,  A61K49/12 ,  A61K51/06 ,  A61K49/00

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific Ti-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific Ti contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US20200290982A1

公开(公告)日：2020-09-17

申请号：US16887754

申请日：2020-05-29

申请人： The Johns Hopkins University ,  Northwestern University

发明人： Sangeeta Ray ,  Martin G. Pomper ,  Thomas J. Meade ,  Ronnie C. Mease ,  Ying Chen ,  Xing Yang ,  Matthew Rotz

IPC分类号： C07D257/02 ,  A61K49/10 ,  A61K51/04 ,  C07D403/14 ,  A61K49/12 ,  A61K51/06 ,  A61K49/00

摘要： Low-molecular weight gadolinium (Gd)-based MR contrast agents for PSMA-specific T1-weighted MR imaging are disclosed. The (Gd)-based MR contrast agents exhibit high binding affinity for PSMA and exhibit specific T1 contrast enhancement at PSMA+ cells. The PSMA-targeted Gd-based MR contrast agents can be used for PSMA-targeted imaging in vivo. 86Y-labeled PSMA-binding ureas also are provided, wherein the PSMA-binding ureas also are suitable for use with other radiotherapeutics.

公开(公告)号：US11078166B2

公开(公告)日：2021-08-03

申请号：US15752340

申请日：2016-08-15

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Martin G. Pomper ,  Ying Chen ,  Xing Yang ,  Ronnie C. Mease ,  Sangeeta Ray

IPC分类号： C07D249/04 ,  A61K51/04 ,  C07B59/00

摘要： Triazole conjugated urea-based and thiourea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used to image cells and tumors that express PSMA. Methods of synthesizing radiofluorinated triazole conjugated urea-based and thiourea-based scaffolds also are disclosed.

公开(公告)号：US20200282083A1

公开(公告)日：2020-09-10

申请号：US16674089

申请日：2019-11-05

申请人： The Johns Hopkins University

发明人： Martin G. Pomper ,  Ronnie Charles Mease ,  Ying Chen

IPC分类号： A61K51/04 ,  C07F7/22 ,  A61K9/127 ,  C07C275/16 ,  C07D213/61 ,  C07D213/74 ,  C07D213/82 ,  C07C275/18

摘要： Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.

公开(公告)号：US20190177275A1

公开(公告)日：2019-06-13

申请号：US16308128

申请日：2017-06-09

申请人： The Johns Hopkins University

发明人： Hayden T. Ravert ,  Daniel P. Holt ,  Ying Chen ,  Ronnie C. Mease ,  Hong Fan ,  Martin G. Pomper ,  Robert F. Dannals

IPC分类号： C07D213/42 ,  A61P35/00 ,  A61K51/04 ,  C07B59/00

摘要： Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.

公开(公告)号：US20240140971A1

公开(公告)日：2024-05-02

申请号：US18209798

申请日：2023-06-14

申请人： The Johns Hopkins University ,  Duke University

发明人： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray ,  Michael Zalutsky ,  Ganesan Vaidyanathan

IPC分类号： C07F13/00 ,  A61P35/00

CPC分类号： C07F13/00 ,  A61P35/00 ,  C07B2200/05

摘要： PSMA binding scaffolds with radioiodinated, radiobrominated and radioastatinated labeled prosthetic groups are disclosed. Pharmaceutical compositions and methods of treating PSMA expressing cells or tumors also are disclosed.

公开(公告)号：US11851407B2

公开(公告)日：2023-12-26

申请号：US17195895

申请日：2021-03-09

申请人： The Johns Hopkins University

发明人： Hayden T. Ravert ,  Daniel P. Holt ,  Ying Chen ,  Ronnie C. Mease ,  Hong Fan ,  Martin G. Pomper ,  Robert F. Dannals

IPC分类号： C07D213/42 ,  A61K51/04 ,  A61P35/00 ,  C07B59/00 ,  C07D213/82

CPC分类号： C07D213/42 ,  A61K51/0455 ,  A61K51/0497 ,  A61P35/00 ,  C07B59/002 ,  C07D213/82

摘要： Methods, and related compositions, for the improved synthesis of [18F]DCFPyL are disclosed. Also provided are methods, and related compositions, for the use of [18F]DCFPyL so produced.

公开(公告)号：US20210308286A1

公开(公告)日：2021-10-07

申请号：US17264220

申请日：2019-07-30

申请人： The Johns Hopkins University ,  University Health Network

发明人： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray ,  Juan Chen ,  Marta Overchuk ,  Kara Harmatys ,  Gang Zheng

IPC分类号： A61K51/08 ,  A61K41/00 ,  A61P35/00 ,  A61K49/00 ,  A61K47/65

摘要： Theranostic probes comprising a porphyrin-based photosensitizer, a D-peptide linker, and a urea-based PSMA-targeting ligand and methods of their use for treating and/or imaging PMSA-expressing tumors are disclosed.

公开(公告)号：US12065413B2

公开(公告)日：2024-08-20

申请号：US17331113

申请日：2021-05-26

申请人： The Johns Hopkins University

发明人： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray

IPC分类号： A61K51/00 ,  A61K49/00 ,  A61K51/04 ,  A61M36/14 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D257/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/02 ,  C07F13/00 ,  G01N33/50

CPC分类号： C07D257/02 ,  A61K49/0032 ,  A61K49/0052 ,  A61K51/0421 ,  A61K51/044 ,  A61K51/0446 ,  A61K51/0453 ,  A61K51/0472 ,  C07D209/12 ,  C07D209/14 ,  C07D209/24 ,  C07D213/04 ,  C07D249/04 ,  C07D255/02 ,  C07D311/14 ,  C07D311/20 ,  C07D311/82 ,  C07F5/027 ,  C07F13/005 ,  G01N33/5091 ,  G01N2800/342

摘要： Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.