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公开(公告)号：US20150265577A1
公开(公告)日：2015-09-24
申请号：US14734564
申请日：2015-06-09
IPC分类号： A61K31/415 , A61K9/00 , A61K45/06 , A61K38/06 , A61K9/127
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K31/095 , A61K38/063 , A61K45/06 , C07D231/10 , C07D231/12 , C07D231/42 , A61K2300/00
摘要： Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.
摘要翻译： 根据本发明的方面提供了包含一种或多种含硒COX-2抑制剂的组合物和药物组合物。 根据本发明的方面提供了治疗患有或怀疑患有癌症的受试者的方法，其包括施用治疗有效量的包含含硒COX-2抑制剂的药物组合物。
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公开(公告)号：US09918966B2
公开(公告)日：2018-03-20
申请号：US15244671
申请日：2016-08-23
IPC分类号： A61K31/095 , A61K31/415 , A61K45/06 , A61K9/127 , A61K9/00 , A61K38/06 , C07D231/12 , C07D231/42 , C07D231/10
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K31/095 , A61K38/063 , A61K45/06 , C07D231/10 , C07D231/12 , C07D231/42 , A61K2300/00
摘要： Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.
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公开(公告)号：US09107947B2
公开(公告)日：2015-08-18
申请号：US14169639
申请日：2014-01-31
IPC分类号： A61K9/127 , C07D231/10 , A61K45/06 , A61K31/415 , A61K31/095 , C07D231/42
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K31/095 , A61K38/063 , A61K45/06 , C07D231/10 , C07D231/12 , C07D231/42 , A61K2300/00
摘要： Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.
摘要翻译： 根据本发明的方面提供了包含一种或多种含硒COX-2抑制剂的组合物和药物组合物。 根据本发明的方面提供了治疗患有或怀疑患有癌症的受试者的方法，其包括施用治疗有效量的包含含硒COX-2抑制剂的药物组合物。
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公开(公告)号：US20230219886A1
公开(公告)日：2023-07-13
申请号：US18007724
申请日：2021-06-02
申请人： María del Carmen SANMARTIN GRIJALBA , Daniel PLANO AMATRIAIN , Ana Carolina RUBERTE SÁNCHEZ , THE PENN STATE RESEARCH FOUNDATION
发明人： Arun K. Sharma , Shantu G. Amin , Mohammad Asif Raza , Ana Carolina Ruberte Sánchez , Daniel Plano Amatriain , María del Carmen Sanmartín Grijalba
IPC分类号： C07C391/00 , A61P35/00 , C07D209/28
CPC分类号： C07C391/00 , A61P35/00 , C07D209/28
摘要： The present invention relates to seleno-NSAID compounds, compositions comprising such compounds, and methods of use. In particular, provided herein are compounds, pharmaceutical compositions, and methods of using of the same for treating cancer and for reducing or inhibiting cancer cell growth in a subject having cancer.
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公开(公告)号：US20130253052A1
公开(公告)日：2013-09-26
申请号：US13785731
申请日：2013-03-05
IPC分类号： C07C391/00 , A61K45/06 , A61K31/21
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
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公开(公告)号：US20130184339A1
公开(公告)日：2013-07-18
申请号：US13785552
申请日：2013-03-05
IPC分类号： C07C391/00 , A61K45/06 , A61K31/21
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
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公开(公告)号：US20160354344A1
公开(公告)日：2016-12-08
申请号：US15244671
申请日：2016-08-23
IPC分类号： A61K31/415 , A61K9/00 , A61K9/127 , C07D231/12
CPC分类号： A61K31/415 , A61K9/0014 , A61K9/127 , A61K9/1271 , A61K31/095 , A61K38/063 , A61K45/06 , C07D231/10 , C07D231/12 , C07D231/42 , A61K2300/00
摘要： Compositions and pharmaceutical compositions including one or more selenium-containing COX-2 inhibitors are provided according to aspects of the present invention. Methods of treating a subject having or suspected of having cancer are provided according to aspects of the present invention which include administering a therapeutically effective amount of a pharmaceutical composition including a selenium-containing COX-2 inhibitor.
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公开(公告)号：US20150376124A1
公开(公告)日：2015-12-31
申请号：US14755390
申请日：2015-06-30
IPC分类号： C07C391/00 , A61K45/06 , A61K9/00 , C07C331/24 , A61K31/26
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
摘要翻译： 描述了抗癌组合物和方法，包括一种或多种异硫氰酸酯和/或异硒氰酸酯。 根据本发明的实施方案提供了治疗受试者的方法，其包括向具有以Akt调节为特征的病症的受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物。 向受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物可检测地增加癌细胞，特别是以Akt失调为特征的癌细胞的凋亡和/或降低增殖。
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公开(公告)号：US09126911B2
公开(公告)日：2015-09-08
申请号：US13785778
申请日：2013-03-05
IPC分类号： A61K31/21 , C07C391/00 , A61K31/095 , A61K45/06 , C07C251/00
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
摘要翻译： 描述了抗癌组合物和方法，包括一种或多种异硫氰酸酯和/或异硒氰酸酯。 根据本发明的实施方案提供了治疗受试者的方法，其包括向具有以Akt调节为特征的病症的受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物。 向受试者施用治疗有效量的包含异硫氰酸酯和/或异硒氰酸酯的组合物可检测地增加癌细胞，特别是以Akt失调为特征的癌细胞的凋亡和/或降低增殖。
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公开(公告)号：US09126910B2
公开(公告)日：2015-09-08
申请号：US13785731
申请日：2013-03-05
IPC分类号： A61K31/21 , C07C391/00 , A61K31/095 , A61K45/06 , C07C251/00
CPC分类号： C07C391/00 , A61K9/0014 , A61K31/095 , A61K31/21 , A61K31/26 , A61K45/06 , C07C251/00 , C07C331/24
摘要： Anti-cancer compositions and methods are described including one or more isothiocyanates and/or isoselenocyanates. Methods of treating a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject having a condition characterized by Akt dysregulation. Administering a therapeutically effective amount of a composition including an isothiocyanate and/or isoselenocyanate to a subject detectably increases apoptosis and/or decreases proliferation of cancer cells, particularly cancer cells characterized by Akt dysregulation.
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