公开(公告)号：US20180235592A1

公开(公告)日：2018-08-23

申请号：US15749981

申请日：2016-08-03

Applicant: The Penn State Research Foundation ,  The Penn State Research Foundation

Inventor： Rena Kass ,  Kristine Widders ,  Barry M. Fell ,  Randy Haluck ,  Peter Dillon

IPC: A61B17/02

CPC classification number: A61B17/0206 ,  A61B17/0218 ,  A61B17/0293 ,  A61B17/3423 ,  A61B90/30 ,  A61B90/92 ,  A61B90/94 ,  A61B2017/00438 ,  A61B2017/00477 ,  A61B2017/00526 ,  A61B2017/00561 ,  A61B2017/00796 ,  A61B2017/00951 ,  A61B2090/0807

Abstract: The device can include a first member connected to a second member via junctions. The members can be statically or pivotally connected at the junctions via arms extending from cross-beams of the members. The junctions can be configured to provide a biasing force. Methods of using the device may include collapsing the device and inserting it through an incision, allowing the biasing force to cause continuous traction and counter-traction adjacent to a leading dissection edge so that retraction of the skin from the tissue can be facilitated during a surgical procedure.

公开(公告)号：US20250064580A1

公开(公告)日：2025-02-27

申请号：US18721082

申请日：2022-12-16

Applicant: Robert DOWLING ,  THE PENN STATE RESEARCH FOUNDATION

Inventor： Robert DOWLING ,  William S. PIERCE ,  Gerson ROSENBERG

IPC: A61F2/24

Abstract: A prosthetic anastomosis fixation device comprising an inner support structure and an outer support structure positioned around the inner support structure and coupled to a prosthetic device, wherein the inner support structure comprises an expandable structure radially movable between an unexpanded to an expanded configuration, wherein in the expanded configuration, the inner support structure provides a radially outward force toward an inner surface of the outer support structure, wherein the inner and outer support structures are sized and configured to receive a portion of a biological conduit therebetween such that in the expanded configuration, the portion of a biological conduit is fixedly secured between the inner surface of the outer support structure and an outer surface of the inner support structure.

公开(公告)号：US12233419B2

公开(公告)日：2025-02-25

申请号：US17259136

申请日：2019-07-11

Applicant: The Penn State Research Foundation

Inventor： Pak Kin Wong ,  Hui Li

IPC: B01L3/00 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/689

Abstract: Provided are devices and methods for detecting the presence, absence, and/or characteristics of bacteria. A microfluidic device for characterizing bacteria is provided. The device contains one or more bacteria trapping channels, and one or more pneumatic channels in contact with the bacteria trapping channels, wherein the one or more pneumatic channels are configured to reduce the height of the one or more bacteria trapping channels to thereby trap bacteria in the one or more bacteria trapping channels if said bacteria are present in a liquid biological sample that is introduced into the microfluidic device. Also provided is a method for identifying bacteria that may be used with the microfluidic device.

公开(公告)号：US20250059871A1

公开(公告)日：2025-02-20

申请号：US18938602

申请日：2024-11-06

Applicant: The Penn State Research Foundation

Inventor： Arash Dahi Taleghani

IPC: E21B43/267 ,  C09K8/80

Abstract: Tuning fracture hydraulic conductivity can be provided so that high hydraulic conductivity in high temperature zones and low hydraulic conductivity in low temperature zones can be defined in enhanced geothermal systems (EGS). Uniform thermal gradient along flow paths can be provided or defined to help provide such conductivity zones. Experimentation performed to evaluate embodiments showed that embodiments could prevent appearance of dominant flow paths between the wells and maintain high heat extraction rates. Embodiments can greatly increase cumulative heat extraction. Embodiments can also be provided for application solely to the injection wells. Other embodiments can position tuning agents between the wells and still help provide control of the fluid flow in the reservoir and enhance heat extraction.

公开(公告)号：US12220667B2

公开(公告)日：2025-02-11

申请号：US17645380

申请日：2021-12-21

Applicant: THE PENN STATE RESEARCH FOUNDATION

Inventor： Manish Kumar ,  Tingwei Ren ,  Woochul Song ,  Yu-Ming Tu

IPC: B01D67/00 ,  B01D69/14 ,  B01D71/24 ,  B01D71/26 ,  B01D71/52 ,  B01D71/56 ,  B01D71/80 ,  C07K14/245 ,  C07K14/31 ,  C07K14/47

Abstract: The present disclosure describes compositions and methods for preparing membrane protein nanosheets and two-dimensional crystals. In particular, the methods employ a solvent. A mixture of a polymer and a membrane protein is solubilized in the solvent, applied to a substrate, and subsequently dried to form the nanosheet or two-dimensional crystal. Applicants have surprisingly found that the membrane proteins maintain their structure when exposed to solvents during the short processing time utilized.

公开(公告)号：US20250027858A1

公开(公告)日：2025-01-23

申请号：US18775741

申请日：2024-07-17

Applicant: The Penn State Research Foundation

Inventor： James Charles Slosson ,  Hojae Yi

IPC: G01N3/10 ,  G01N3/24 ,  G01N33/483

Abstract: Methods and systems facilitate measuring flow properties of a material, such as biomass materials, that include different material particles. Sample holding plates securely hold material particles and secure them to sample holders. A normal force actuator applies a normal force between material particles held by the sample holding plates and a sliding force actuator applies a sliding force. Normal and sliding force sensors monitor the transmitted forces, allowing a processor to determine adhesion and friction characteristics between particles held by the first and second sample holding plates.

公开(公告)号：US20240417972A1

公开(公告)日：2024-12-19

申请号：US18705355

申请日：2022-10-28

Applicant: The Penn State Research Foundation

Inventor： Yun Jing ,  Jun Ji

IPC: E04B1/86 ,  E04B1/84

Abstract: A sound absorbing panel includes a cavity section having a plurality of resonant cavities and a front panel having a plurality of sets of openings. Each set of openings is configured to provide fluid communication between one of the plurality of resonant cavities and the environment. Each of the plurality of resonant cavities has different dimensions from the remaining plurality of resonant cavities such that each of the resonant cavities is tuned for a different frequency range. Each of the sets of openings can differ from the remaining sets of openings in opening size, length, and distance between openings.

公开(公告)号：US12152450B2

公开(公告)日：2024-11-26

申请号：US18560197

申请日：2022-05-25

Applicant: The Penn State Research Foundation

Inventor： Amin Mehrabian ,  Wei Zhang ,  Pooya Khodaparast

IPC: E21B21/08 ,  E21B47/06

Abstract: Embodiments relate to a flow loop system for estimating wellbore circulation density. The flow loop system includes an eccentric annulus structure having an inner eccentric pipe and an outer pipe. The inner eccentric pipe can be representative of a drill string in a wellbore. The outer pipe can be representative of the wellbore. The flow loop system includes a pressure sensor configured to measure pressure loss gradients of annular flows between the inner eccentric pipe and the outer pipe. The flow loop system includes a wellbore circulation density processing module configured to estimate the wellbore's bottomhole pressure based on the measured loss gradients of annular flows of fluid and solid particles, rotation of the inner eccentric pipe, and eccentricity of the inner eccentric pipe.

公开(公告)号：US20240307331A1

公开(公告)日：2024-09-19

申请号：US18173743

申请日：2021-08-23

Applicant: Abrexa Pharmaceuticals, Inc. ,  The Penn State Research Foundation

Inventor： Jesus E. VILLAFRANCA ,  Charles Richard KISSINGER ,  Guohong LI

IPC: A61K31/167 ,  A61K38/48 ,  A61P7/04 ,  A61P9/10

CPC classification number: A61K31/167 ,  A61K38/482 ,  A61P7/04 ,  A61P9/10 ,  C12Y304/21068

Abstract: Hemorrhage and vascular instability can be induced by thrombolytic and anti-coagulant therapies. Presented herein, in certain aspects, are methods for the treatment and/or prevention of hemorrhage and vascular instability that comprise administering a compound disclosed herein to a subject in need thereof.

公开(公告)号：US20240276648A1

公开(公告)日：2024-08-15

申请号：US18561934

申请日：2022-03-30

Applicant: The Penn State Research Foundation

Inventor： Ning Yi ,  Yuyan Gao ,  Antonino Lo Verso, Jr. ,  Jia Zhu ,  Daniel Erdely ,  Robert Lavelle ,  Huanyu Cheng

IPC: H05K3/14 ,  A61B5/28 ,  A61B5/296 ,  H05K1/09

CPC classification number: H05K3/143 ,  A61B5/28 ,  A61B5/296 ,  H05K1/092 ,  H05K3/146 ,  H05K2203/0156 ,  H05K2203/0557 ,  H05K2203/083 ,  H05K2203/1131 ,  H05K2203/1173

Abstract: The invention includes methods of forming electronic circuitry on a target surface using intense pulsed light-induced mass transfer (IPLMT) of metal nanoparticles (NPs) by applying a pliable mask to a target surface, coating a carrier film with metal NPs, mounting the carrier film to the target surface and over the pliable mask so that the pliable mask is sandwiched between the target surface and the metal NPs. and exposing the metal NPs to light energy to cause atoms of the metal NPs to evaporate and transport through openings of the pliable mask and condense on the target surface, producing a conductive pattern of condensed metal on the target surface. Certain implementations may utilize a kirigami-patterned pliable mask to enhance conformity to a freeform 3D target surface. In certain implementations, zinc (Zn) may be formed by IPLMT of Zn NPs to the target surface.