专利检索 ap:("The Queen's University of Belfast") AND inv:"Adrien KISSENPFENG" 第 1 页

1.

发明申请
USE OF FKBP-L POLYPEPTIDES AND NUCLEIC ACIDS FOR THE TREATMENT OF OBESITY 审中-公开

公开(公告)号：US20190247462A1

公开(公告)日：2019-08-15

申请号：US16343266

申请日：2017-10-18

申请人： The Queen's University of Belfast

发明人： Tracy ROBSON , David GRIEVE , Amy SHORT , Adrien KISSENPFENG , Marie MIGAUD , Rachel BENNETT , Anita YAKKUNDI , Helen MCCARTHY

IPC分类号： A61K38/17 , A61P3/04 , A61P3/10 , A61K9/00

CPC分类号： A61K38/1709 , A61K9/0019 , A61K38/17 , A61P3/04 , A61P3/10

摘要： The inventors have determined that increasing the expression level or activity of FKBP-L polypeptide in a subject, which can be provided by expression of nucleic acids encoding FKBP-L or by providing FKBP-L polypeptides to a subject is advantageous for use in the treatment of obesity and obesity-related disorders. In particular increased expression or activity of FKBP-L polypeptide in a subject may be used to treat excessive weight gain (which can be characterised as obesity), glucose intolerance, diabetes and metabolic syndrome, which are closely linked to obesity and insulin resistance. FKBP-L can also be used as a biomarker for obesity and obesity-related disorders.