公开(公告)号：US20200291055A1

公开(公告)日：2020-09-17

申请号：US16886985

申请日：2020-05-29

申请人： The Queen's University of Belfast

发明人： Marie MIGAUD ,  Philip REDPATH ,  Kerri CROSSEY ,  Mark DOHERTY

IPC分类号： C07H19/048 ,  C07H1/00 ,  C07H1/06

摘要： Methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I) wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido;R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; andX− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

公开(公告)号：US20190247462A1

公开(公告)日：2019-08-15

申请号：US16343266

申请日：2017-10-18

申请人： The Queen's University of Belfast

发明人： Tracy ROBSON ,  David GRIEVE ,  Amy SHORT ,  Adrien KISSENPFENG ,  Marie MIGAUD ,  Rachel BENNETT ,  Anita YAKKUNDI ,  Helen MCCARTHY

IPC分类号： A61K38/17 ,  A61P3/04 ,  A61P3/10 ,  A61K9/00

CPC分类号： A61K38/1709 ,  A61K9/0019 ,  A61K38/17 ,  A61P3/04 ,  A61P3/10

摘要： The inventors have determined that increasing the expression level or activity of FKBP-L polypeptide in a subject, which can be provided by expression of nucleic acids encoding FKBP-L or by providing FKBP-L polypeptides to a subject is advantageous for use in the treatment of obesity and obesity-related disorders. In particular increased expression or activity of FKBP-L polypeptide in a subject may be used to treat excessive weight gain (which can be characterised as obesity), glucose intolerance, diabetes and metabolic syndrome, which are closely linked to obesity and insulin resistance. FKBP-L can also be used as a biomarker for obesity and obesity-related disorders.

公开(公告)号：US20180186824A1

公开(公告)日：2018-07-05

申请号：US15905922

申请日：2018-02-27

申请人： The Queen's University of Belfast

发明人： Marie MIGAUD ,  Philip REDPATH ,  Kerri CROSSEY ,  Mark DOHERTY

IPC分类号： C07H19/048 ,  C07H1/06 ,  C07H1/00 ,  C07H19/04

摘要： The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

公开(公告)号：US20240101588A1

公开(公告)日：2024-03-28

申请号：US18307733

申请日：2023-04-26

申请人： The Queen's University of Belfast

发明人： Marie MIGAUD ,  Philip REDPATH ,  Kerri CROSSEY ,  Mark DOHERTY

IPC分类号： C07H19/048 ,  C07H1/00 ,  C07H1/06

CPC分类号： C07H19/048 ,  C07H1/00 ,  C07H1/06 ,  C07H19/04

摘要： Methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I)




wherein



n is 0 or 1;
m is 0 or 1;
Y is O or S;
R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido;
R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and
X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

公开(公告)号：US20160168184A1

公开(公告)日：2016-06-16

申请号：US14908831

申请日：2014-07-24

申请人： THE QUEEN'S UNIVERSITY OF BELFAST

发明人： Marie MIGAUD ,  Philip REDPATH ,  Kerri CROSSEY ,  Mark DOHERTY

IPC分类号： C07H19/048 ,  C07H1/06

CPC分类号： C07H19/048 ,  C07H1/00 ,  C07H1/06 ,  C07H19/04 ,  Y02P20/582

摘要： The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a compound of formula (I), wherein n is 0 or 1; m is 0 or 1; Y is O or S; R1 is selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; R2-R5, which may be the same or different, are each independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl, and substituted or unsubstituted aryl; and X− is an anion, selected from an anion of a substituted or unsubstituted carboxylic acid, a halide, a substituted or unsubstituted sulfonate, a substituted or unsubstituted phosphate, a substituted or unsubstituted sulfate, a substituted or unsubstituted carbonate, and a substituted or unsubstituted carbamate.

摘要翻译： 本发明涉及制备烟酰胺核苷及其衍生物的方法。 一方面，本发明涉及制备式（I）化合物的方法，其中n为0或1; m为0或1; Y为O或S; R 1选自H，取代或未取代的烷基，取代或未取代的烯基，取代或未取代的炔基，取代或未取代的芳基，取代或未取代的伯或仲氨基，以及取代或未取代的叠氮基; R 2 -R 5可以相同或不同，各自独立地选自H，取代或未取代的烷基，取代或未取代的烯基，或取代或未取代的炔基，以及取代或未取代的芳基; 并且X是阴离子，其选自取代或未取代的羧酸的阴离子，卤化物，取代或未取代的磺酸酯，取代或未取代的磷酸酯，取代或未取代的硫酸酯，取代或未取代的碳酸酯， 未取代的氨基甲酸酯。