公开(公告)号：US20030211080A1

公开(公告)日：2003-11-13

申请号：US10342120

申请日：2003-01-13

申请人： The Regents of University of California

发明人： Wolfgang H. Dillmann ,  Frank Giordano ,  Ruben Mestril

IPC分类号： A61K048/00 ,  C12N015/861

CPC分类号： C12N9/14 ,  A01K2267/0375 ,  A61K38/00 ,  A61K48/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2750/14143 ,  C12Y306/03008

摘要： A method for regulating in vivo calcium transport in cardiac muscle of animals suffering from congestive heart failure is disclosed. According to the method, calcium ATPase activity (which decreases as congestive heart failure develops) and cardiac muscle contractility augmented by delivering a gene which operatively encodes the enzyme into the heart. Delivery systems, including but not limited to using adeno-associated viral vectors are provided. Methods for monitoring the expression and effect of the gene product on cardiac performance are also provided.

摘要翻译： 公开了一种用于调节患有充血性心力衰竭的动物心肌肌体内钙转运的方法。 根据该方法，通过将可操作地编码酶的基因递送到心脏中，钙ATP酶活性（其随着充血性心力衰竭发展而减少）和心肌收缩力增加。 提供递送系统，包括但不限于使用腺相关病毒载体。 还提供了监测基因产物对心脏性能的表达和作用的方法。