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公开(公告)号：US11608378B2
公开(公告)日：2023-03-21
申请号：US17151009
申请日：2021-01-15
发明人： Stephen L. Nishimura , Anthony Cormier , Saburo Ito , Jianlong Lou , James D. Marks , Yifan Cheng , Melody G. Campbell , Jody L. Baron
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/28
摘要： Antibodies that bind to ανβ8 are provided.
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公开(公告)号：US20230279119A1
公开(公告)日：2023-09-07
申请号：US18153103
申请日：2023-01-11
发明人： Stephen L. Nishimura , Anthony Cormier , Saburo Ito , Jianlong Lou , James D. Marks , Yifan Cheng , Melody G. Campbell , Jody L. Baron
IPC分类号： C07K16/28
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565
摘要： Antibodies that bind to αvβ8 are provided.
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公开(公告)号：US20210230279A1
公开(公告)日：2021-07-29
申请号：US17155784
申请日：2021-01-22
发明人： Stephen L. Nishimura , Jianlong Lou , James D. Marks , Jody L. Baron , Yifan Cheng , Shenping Wu , Anthony Cormier , Naoki Takasaka
IPC分类号： C07K16/28 , A61P31/20 , A61P35/04 , A61P37/04 , A61P1/04 , C07K14/705 , C07K16/22 , G01N33/563
摘要： New antibodies and methods of use are described.
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公开(公告)号：US20210277125A1
公开(公告)日：2021-09-09
申请号：US17151009
申请日：2021-01-15
发明人： Stephen L. Nishimura , Anthony Cormier , Saburo Ito , Jianlong Lou , James D. Marks , Yifan Cheng , Melody G. Campbell , Jody L. Baron
IPC分类号： C07K16/28
摘要： Antibodies that bind to αv⊖8 are provided.
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公开(公告)号：US10954304B2
公开(公告)日：2021-03-23
申请号：US16331902
申请日：2017-09-29
发明人： Stephen L. Nishimura , Jianlong Lou , James D. Marks , Jody L. Baron , Yifan Cheng , Shenping Wu , Anthony Cormier , Naoki Takasaka
IPC分类号： C07K16/00 , C07K16/46 , C07K16/28 , A61P31/20 , A61P35/04 , A61P37/04 , A61P1/04 , C07K14/705 , C07K16/22 , G01N33/563 , A61K39/00
摘要： Provided is an antibody that specifically binds human αvββ and blocks binding of TGFp peptide to αvβ8, wherein the antibody binds to the specificity determining loop (SDL) of human β8. In some embodiments, the antibody further binds to one, two, or all three of the human av-head domain, the al helix of human β8, or the al helix of human β8. In some embodiments, the antibody is humanized or chimeric. In some embodiments, the antibody is linked to a detectable label. Also provided is a method of enhancing an immune response in a human individual, comprising administering a sufficient amount of the antibody to the individual, thereby enhancing an immune response. Also provided are pharmaceutical compositions comprising the anti-αvββ antibodies or antigen-binding molecules thereof.
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公开(公告)号：US12110334B2
公开(公告)日：2024-10-08
申请号：US18153277
申请日：2023-01-11
发明人： Stephen L. Nishimura , Jianlong Lou , James D. Marks , Jody L. Baron , Yifan Cheng , Shenping Wu , Anthony Cormier , Naoki Takasaka
IPC分类号： G01N33/53 , A61P1/04 , A61P31/20 , A61P35/04 , A61P37/04 , C07K14/705 , C07K16/00 , C07K16/22 , C07K16/28 , C07K16/46 , G01N33/563 , A61K39/00
CPC分类号： C07K16/2839 , A61P1/04 , A61P31/20 , A61P35/04 , A61P37/04 , C07K14/705 , C07K16/22 , G01N33/563 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： New antibodies and methods of use are described.
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公开(公告)号：US20230331851A1
公开(公告)日：2023-10-19
申请号：US18153277
申请日：2023-01-11
发明人： Stephen L. Nishimura , Jianlong Lou , James D. Marks , Jody L. Baron , Yifan Cheng , Shenping Wu , Anthony Cormier , Naoki Takasaka
IPC分类号： C07K16/28 , A61P31/20 , A61P35/04 , A61P37/04 , A61P1/04 , C07K14/705 , C07K16/22 , G01N33/563
CPC分类号： C07K16/2839 , A61P31/20 , A61P35/04 , A61P37/04 , A61P1/04 , C07K14/705 , C07K16/22 , G01N33/563 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K2039/505
摘要： New antibodies and methods of use are described.
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公开(公告)号：US11591402B2
公开(公告)日：2023-02-28
申请号：US17155784
申请日：2021-01-22
发明人： Stephen L. Nishimura , Jianlong Lou , James D. Marks , Jody L. Baron , Yifan Cheng , Shenping Wu , Anthony Cormier , Naoki Takasaka
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/28 , A61P31/20 , A61P35/04 , A61P37/04 , A61P1/04 , C07K14/705 , C07K16/22 , G01N33/563
摘要： New antibodies and methods of use are described.
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