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公开(公告)号：US10603356B2
公开(公告)日：2020-03-31
申请号：US15135060
申请日：2016-04-21
Applicant: The Regents of the University of California
Inventor： Michael E. Selsted , Dat Q. Tran
Abstract: A method is provided for treating bowel disease related to the activity of TNF-α, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
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Patent Agency Ranking
公开(公告)号：US20160303194A1
公开(公告)日：2016-10-20
申请号：US15135060
申请日：2016-04-21
Applicant: The Regents of the University of California
Inventor： Michael E. Selsted , Dat Q. Tran
Abstract: A method is provided for treating bowel disease related to the activity of TNF-α, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
Abstract translation: 提供了通过施用θ-防御素，类似物或衍生物来治疗与TNF-α的活性相关的肠病的方法。 这种θ-防御素，类似物或衍生物可以有效地肠胃外，局部地或口服地施用。 可以选择θ-防御素，类似物或衍生物来另外抑制ADAM-10活性。
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公开(公告)号：US20150080319A1
公开(公告)日：2015-03-19
申请号：US14491661
申请日：2014-09-19
Applicant: The Regents of the University of California
Inventor： Michael E. Selsted , Dat Q. Tran
IPC: C07K14/47
CPC classification number: A61K38/1729 , A61K9/0053 , A61K38/10 , A61K38/12 , A61K38/55 , C07K14/4723
Abstract: A method is provided for inhibiting TACE activity in a human subject, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
Abstract translation: 提供了一种通过施用“抑菌素”，“类似物”或“衍生物”来抑制人受试者TACE活性的方法。 可以有效地肠胃外，局部地或口服地施用这样的一种＆amp; s-防腐素，类似物或衍生物。 可以选择＆amp; t;防腐素，类似物或衍生物来另外抑制ADAM-10活性。
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公开(公告)号：US12186368B2
公开(公告)日：2025-01-07
申请号：US16825221
申请日：2020-03-20
Applicant: The Regents of the University of California
Inventor： Michael E. Selsted , Dat Q. Tran
IPC: A61K38/17 , A61K9/00 , A61K38/10 , A61K38/12 , A61K38/55 , C07K14/47 , F01P5/04 , F24F5/00 , F24F6/16 , B63J3/00
Abstract: A method is provided for a condition related to the activity of a protease through the administration of a θ-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.
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公开(公告)号：US20200333024A1
公开(公告)日：2020-10-22
申请号：US16825221
申请日：2020-03-20
Applicant: The Regents of the University of California
Inventor： Michael E. Selsted , Dat Q. Tran
Abstract: A method is provided for a condition related to the activity of a protease through the administration of a θ-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.
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公开(公告)号：US09346866B2
公开(公告)日：2016-05-24
申请号：US14491661
申请日：2014-09-19
Applicant: The Regents of the University of California
Inventor： Michael E. Selsted , Dat Q. Tran
CPC classification number: A61K38/1729 , A61K9/0053 , A61K38/10 , A61K38/12 , A61K38/55 , C07K14/4723
Abstract: A method is provided for inhibiting TACE activity in a human subject, through the administration of a θ-defensin, analog, or derivative. Such a θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally. The θ-defensin, analog, or derivative can be selected to additionally inhibit ADAM-10 activity.
Abstract translation: 提供了一种通过施用“抑菌素”，“类似物”或“衍生物”来抑制人受试者的TACE活性的方法。 可以有效地肠胃外，局部地或口服地施用这样的一种＆amp; s-防腐素，类似物或衍生物。 可以选择＆amp; t;防腐素，类似物或衍生物来另外抑制ADAM-10活性。
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