公开(公告)号：US20210340496A1

公开(公告)日：2021-11-04

申请号：US17284396

申请日：2019-10-10

Applicant: The Regents of the University of California

Inventor： Alexander Marson ,  Jessica T. Cortez ,  Jeffrey A. Bluestone ,  Eric Shifrut ,  Frederic Van Gool

IPC: C12N5/0783 ,  C12N15/90 ,  A61K35/17 ,  C12N15/11 ,  C12N9/22

Abstract: Provided herein are compositions and methods for modifying regulatory T cells. The inventors have identified nuclear factors that influence expression of Foxp3, a key transcriptional regulator of Treg cells. Treg cells can be modified by inhibiting and/or overexpressing one or more of these nuclear factors to produce stabilized Treg cells or destabilized Treg cells.