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公开(公告)号：US20200245893A1
公开(公告)日：2020-08-06
申请号：US16854557
申请日：2020-04-21
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
Abstract: A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.
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公开(公告)号：US20160135710A1
公开(公告)日：2016-05-19
申请号：US14971768
申请日：2015-12-16
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
CPC classification number: A61B5/0515 , A61B5/7239 , A61B2576/00 , G01N27/72 , G01R33/10 , G01R33/1276
Abstract: A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.
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公开(公告)号：US11231469B2
公开(公告)日：2022-01-25
申请号：US15998525
申请日：2018-08-16
Applicant: The Regents of the University of California
Inventor： Steven M. Conolly , Patrick W. Goodwill , Daniel Hensley , Zhi Wei Tay , Bo Zheng
Abstract: A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion.
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公开(公告)号：US10667716B2
公开(公告)日：2020-06-02
申请号：US15674234
申请日：2017-08-10
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
Abstract: A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.
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公开(公告)号：US10048224B2
公开(公告)日：2018-08-14
申请号：US14328560
申请日：2014-07-10
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
Abstract: A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scaled to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.
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Patent Agency Ranking
公开(公告)号：US20180206757A1
公开(公告)日：2018-07-26
申请号：US15674234
申请日：2017-08-10
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
CPC classification number: A61B5/0515 , A61B5/7239 , A61B2576/00 , G01N27/72 , G01R33/10 , G01R33/1276
Abstract: A magnetic particle imaging device is provided. The device includes a magnetic field source configured to produce a magnetic field having a non-saturating magnetic field region, an excitation signal source configured to produce an excitation signal in the non-saturating magnetic field region that produces a detectable signal from magnetic particles in the non-saturating magnetic field region, and a signal processor configured to convert a detected signal into an image of the magnetic particles. Aspects of the present disclosure also include methods of imaging magnetic particles in a sample, and methods of producing an image of magnetic particles in a subject. The subject devices and methods find use in a variety of applications, such as medical imaging applications.
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公开(公告)号：US11709212B2
公开(公告)日：2023-07-25
申请号：US17581684
申请日：2022-01-21
Applicant: The Regents of the University of California
Inventor： Steven M. Conolly , Patrick W. Goodwill , Daniel Hensley , Zhi Wei Tay , Bo Zheng
CPC classification number: G01R33/1276 , G01R33/10
Abstract: A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion.
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公开(公告)号：US20220221537A1
公开(公告)日：2022-07-14
申请号：US17581684
申请日：2022-01-21
Applicant: The Regents of the University of California
Inventor： Steven M. Conolly , Patrick W. Goodwill , Daniel Hensley , Zhi Wei Tay , Bo Zheng
Abstract: A pulsed magnetic particle imaging system includes a magnetic field generating system that includes at least one magnet, the magnetic field generating system providing a spatially structured magnetic field within an observation region of the magnetic particle imaging system such that the spatially structured magnetic field will have a field-free region (FFR) for an object under observation having a magnetic nanoparticle tracer distribution therein. The pulsed magnetic particle imaging system also includes a pulsed excitation system arranged proximate the observation region, the pulsed excitation system includes an electromagnet and a pulse sequence generator electrically connected to the electromagnet to provide an excitation waveform to the electromagnet, wherein the electromagnet when provided with the excitation waveform generates an excitation magnetic field within the observation region to induce an excitation signal therefrom by at least one of shifting a location or condition of the FFR. The pulsed magnetic particle imaging system further includes a detection system arranged proximate the observation region, the detection system being configured to detect the excitation signal to provide a detection signal. The excitation waveform includes a transient portion and a substantially constant portion.
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公开(公告)号：US11054392B2
公开(公告)日：2021-07-06
申请号：US16040801
申请日：2018-07-20
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
Abstract: A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scamled to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.
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公开(公告)号：US20150008910A1
公开(公告)日：2015-01-08
申请号：US14328560
申请日：2014-07-10
Applicant: The Regents of the University of California
Inventor： Patrick W. Goodwill , Steven M. Conolly
CPC classification number: G01N27/72 , A61B5/05 , A61B5/0515 , A61B5/7257 , G01R33/00 , G01R33/0213 , G01R33/10 , G01R33/1269 , G01R33/1276
Abstract: A magnetic particle imaging apparatus includes magnets [106,107] that produce a gradient magnetic field having a field free region (FFR), excitation field electromagnets [102,114] that produce a radiofrequency magnetic field within the field free region, high-Q receiving coils [112] that detect a response of magnetic particles in the field free region to the excitation field. Field translation electromagnets create a homogeneous magnetic field displacing the field-free region through the field of view (FOV) allowing the imaging region to be scaled to optimize scan time, scanning power, amplifier heating, SAR, dB/dt, and/or slew rate. Efficient multi-resolution scanning techniques are also provided. Intermodulated low and radio-frequency excitation signals are processed to produce an image of a distribution of the magnetic nanoparticles within the imaging region. A single composite image is computed using deconvolution of multiple signals at different harmonics.
Abstract translation: 磁性粒子成像装置包括产生具有无场区域（FFR）的梯度磁场的磁体[106,107]，在无场区域内产生射频磁场的激励场电磁体[102,114]，高Q接收线圈[112 ]，其检测在无场区域中的磁性颗粒对激发场的响应。 场平移电磁铁产生均匀的磁场，通过视场（FOV）移动无场区域，允许成像区域被缩放以优化扫描时间，扫描功率，放大器加热，SAR，dB / dt和/或转换 率。 还提供了高效的多分辨率扫描技术。 处理互调低频和射频激励信号以产生成像区域内磁性纳米颗粒分布的图像。 使用不同谐波处的多个信号的去卷积来计算单个合成图像。
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