公开(公告)号：US10449182B2

公开(公告)日：2019-10-22

申请号：US14408280

申请日：2013-06-20

申请人： The Regents of the University of California

发明人： Robert H. Weiss ,  Bruce D. Hammock ,  Hiromi Inoue Wettersten ,  Sung Hee Hwang

IPC分类号： A61K31/44 ,  A61K31/4439 ,  A61K31/17 ,  A61K31/192 ,  A61K31/277 ,  A61P35/02 ,  A61P35/00 ,  A61K31/4412 ,  A61K45/06 ,  A61K31/196 ,  A61K31/675 ,  A61K31/704 ,  A61K33/24

摘要： The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.

公开(公告)号：US20150132408A1

公开(公告)日：2015-05-14

申请号：US14408280

申请日：2013-06-20

申请人： The Regents of the University of California

发明人： Robert H. Weiss ,  Bruce D. Hammock ,  Hiromi Inoue ,  Sung Hee Hwang

IPC分类号： A61K31/4412 ,  A61K45/06 ,  A61K31/17 ,  A61K31/4439 ,  A61K31/196 ,  A61K31/277

CPC分类号： A61K31/4412 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/675 ,  A61K31/704 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.

摘要翻译： 本发明提供了用于治疗由p21介导的疾病的方法的索拉非尼类似物，所述方法包括向有需要的受试者施用治疗有效量的式I化合物。本发明还提供了抑制p21的化合物的方法 包括使细胞与有效量的式I化合物接触的细胞。