公开(公告)号：US11426385B2

公开(公告)日：2022-08-30

申请号：US16641430

申请日：2018-08-14

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  United States as represented by the Department of Veterans Affairs

发明人： Bruce D. Hammock ,  Sung Hee Hwang ,  Ralph W. de Vere White ,  Chong-xian Pan ,  Hongyong Zhang ,  Paul Henderson ,  Ai-Hong Ma ,  Maike Zimmermann ,  Fuli Wang

IPC分类号： A61K31/415 ,  A61P35/00 ,  A61K33/243 ,  A61K31/7068 ,  A61K45/06

摘要： Provided are methods and compositions for prolonging survival and/or reducing or inhibiting tumor growth in a cancer subject receiving a regimen of one or more chemotherapeutic agents, an inhibitor of soluble epoxide hydrolase (sEHi) and a non-steroidal anti-inflammatory drug (NSAID) that inhibits one or more enzymes selected from the group consisting of cyclo-oxygenase (“COX”)-1, COX-2, and 5-lipoxygenase (“5-LOX”). The methods and compositions decrease toxicity and/or adverse side effects in subjects receiving a regimen of one or more chemotherapeutic agents.

公开(公告)号：US10449182B2

公开(公告)日：2019-10-22

申请号：US14408280

申请日：2013-06-20

申请人： The Regents of the University of California

发明人： Robert H. Weiss ,  Bruce D. Hammock ,  Hiromi Inoue Wettersten ,  Sung Hee Hwang

IPC分类号： A61K31/44 ,  A61K31/4439 ,  A61K31/17 ,  A61K31/192 ,  A61K31/277 ,  A61P35/02 ,  A61P35/00 ,  A61K31/4412 ,  A61K45/06 ,  A61K31/196 ,  A61K31/675 ,  A61K31/704 ,  A61K33/24

摘要： The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.

公开(公告)号：US20150132408A1

公开(公告)日：2015-05-14

申请号：US14408280

申请日：2013-06-20

申请人： The Regents of the University of California

发明人： Robert H. Weiss ,  Bruce D. Hammock ,  Hiromi Inoue ,  Sung Hee Hwang

IPC分类号： A61K31/4412 ,  A61K45/06 ,  A61K31/17 ,  A61K31/4439 ,  A61K31/196 ,  A61K31/277

CPC分类号： A61K31/4412 ,  A61K31/17 ,  A61K31/196 ,  A61K31/277 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/675 ,  A61K31/704 ,  A61K33/24 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention provides sorafenib analogs for use in a method of treating a disease mediated by p21, said method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I. The present invention also provides methods of inhibiting p21 in a cell comprising contacting the cell with an effective amount of a compound of formula I.

摘要翻译： 本发明提供了用于治疗由p21介导的疾病的方法的索拉非尼类似物，所述方法包括向有需要的受试者施用治疗有效量的式I化合物。本发明还提供了抑制p21的化合物的方法 包括使细胞与有效量的式I化合物接触的细胞。

公开(公告)号：US10689595B2

公开(公告)日：2020-06-23

申请号：US16275293

申请日：2017-08-16

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF MASSACHUSETTS

发明人： Guodong Zhang ,  Bruce Hammock ,  Sung Hee Hwang ,  Weicang Wang

IPC分类号： C11C3/12 ,  C11C3/14 ,  C07C67/343 ,  C07C67/303 ,  C07C51/09 ,  A61P35/00

摘要： The present invention provides a synthetic chemical method for preparing ω-hydroxylated polyunsaturated fatty acids (PUFAs) including 20-hydroxyeicosatetraenoic acid (20-HETE), 20-hydroxyeicosapentaenoic acid (20-HEPE), and 22-hydroxydocosahexaenoic acid (22-HDoHE) and a method of use thereof for treating cancer and macular degeneration.

公开(公告)号：US20240342196A1

公开(公告)日：2024-10-17

申请号：US18634143

申请日：2024-04-12

申请人： The UAB Research Foundation ,  The Regents of the University of California

发明人： Sansanka Ramanadham ,  Tayleur D. White ,  Bruce Hammock ,  Sung Hee Hwang

IPC分类号： A61K31/64 ,  A61K31/202 ,  A61K31/4468 ,  A61P3/10

CPC分类号： A61K31/64 ,  A61K31/202 ,  A61K31/4468 ,  A61P3/10

摘要： Disclosed herein are lipid signaling pathways that can be targeted to prevent or delay the onset of type 1 diabetes (T1D). In particular, disclosed herein a pathway that can be modulated by a chemical inhibitor. Utilizing this inhibitor, evidence was generated suggesting that it is beneficial in reducing the incidence of T1D.

公开(公告)号：US11001783B2

公开(公告)日：2021-05-11

申请号：US16867237

申请日：2020-05-05

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  UNIVERSITY OF MASSACHUSETTS

发明人： Guodong Zhang ,  Bruce Hammock ,  Sung Hee Hwang ,  Weicang Wang

IPC分类号： A61P35/00 ,  C11C3/12 ,  C11C3/14 ,  C07C67/343 ,  C07C67/303 ,  C07C51/09

摘要： The present invention provides a synthetic chemical method for preparing ω-hydroxylated polyunsaturated fatty acids (PUFAs) including 20-hydroxyeicosatetraenoic acid (20-HETE), 20-hydroxyeicosapentaenoic acid (20-HEPE), and 22-hydroxydocosahexaenoic acid (22-HDoHE) and a method of use thereof for treating cancer and macular degeneration.