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公开(公告)号：US20220267808A1
公开(公告)日：2022-08-25
申请号：US17703845
申请日：2022-03-24
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220127645A1
公开(公告)日：2022-04-28
申请号：US17514908
申请日：2021-10-29
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US20220119848A1
公开(公告)日：2022-04-21
申请号：US17514936
申请日：2021-10-29
IPC分类号： C12N15/90 , C12N15/11 , C12N15/63 , C12Q1/686 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A61K38/46 , A01H6/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11242543B2
公开(公告)日：2022-02-08
申请号：US17079070
申请日：2020-10-23
IPC分类号： C12N15/11 , C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , A61K38/46 , C12N15/90 , C12Q1/686 , C12N15/70 , C12N15/74 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US11186849B2
公开(公告)日：2021-11-30
申请号：US17084014
申请日：2020-10-29
IPC分类号： C12N15/11 , C12N15/63 , A61K38/46 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/90 , C12Q1/686 , A01H6/46 , A01K67/027 , C12N15/70 , C12N15/74 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US10988782B2
公开(公告)日：2021-04-27
申请号：US17084020
申请日：2020-10-29
IPC分类号： C12N15/11 , C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , C12N15/70 , C12N15/74 , A01H6/46 , A61K48/00 , C12N15/90 , C12Q1/686 , A61K38/46 , A01K67/027
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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7.发明授权公开(公告)号：US10669560B2
公开(公告)日：2020-06-02
申请号：US16201865
申请日：2018-11-27
IPC分类号： C12N15/11 , C12N15/63 , C12N9/22 , C12N15/113 , C12N15/10 , A61K38/46 , C12N15/90 , C12Q1/686 , C12N15/70 , C12N15/74 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US10563227B2
公开(公告)日：2020-02-18
申请号：US16382097
申请日：2019-04-11
IPC分类号： C12N9/22 , C12N15/113 , C12N15/11 , C12N15/10 , C12N15/63 , C12N15/70 , C12N15/74 , A61K38/46 , C12N15/90 , A01H6/46 , A01K67/027 , C12Q1/686 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US10550407B2
公开(公告)日：2020-02-04
申请号：US16382096
申请日：2019-04-11
IPC分类号： C12N9/22 , C12N15/113 , C12N15/11 , C12N15/10 , C12N15/63 , C12N15/70 , C12N15/74 , A61K38/46 , C12N15/90 , A01H6/46 , A01K67/027 , C12Q1/686 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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公开(公告)号：US10513712B2
公开(公告)日：2019-12-24
申请号：US16382093
申请日：2019-04-11
IPC分类号： C12N9/22 , C12N15/113 , C12N15/11 , C12N15/10 , C12N15/63 , C12N15/70 , C12N15/74 , A61K38/46 , C12N15/90 , A01H6/46 , A01K67/027 , A61K48/00
摘要： The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target DNA and/or a polypeptide associated with the target DNA. The present disclosure further provides site-specific modifying polypeptides. The present disclosure further provides methods of site-specific modification of a target DNA and/or a polypeptide associated with the target DNA The present disclosure provides methods of modulating transcription of a target nucleic acid in a target cell, generally involving contacting the target nucleic acid with an enzymatically inactive Cas9 polypeptide and a DNA-targeting RNA. Kits and compositions for carrying out the methods are also provided. The present disclosure provides genetically modified cells that produce Cas9; and Cas9 transgenic non-human multicellular organisms.
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