公开(公告)号：US20230073248A1

公开(公告)日：2023-03-09

申请号：US17820808

申请日：2022-08-18

申请人： The Regents of the University of Colorado. a body Corporate ,  Angimmune LLC ,  The General Hospital Corporation

发明人： Christene A. Huang ,  David M. Neville, JR. ,  Elizabeth Anne Pomfret ,  Raimon Duran-Struuck ,  Zhirui Wang

IPC分类号： A61K39/395 ,  A61K35/14 ,  A61K38/45 ,  A61K31/436 ,  A61K31/5377 ,  A61K31/573 ,  A61K31/58 ,  A61K31/519 ,  A61K38/13 ,  A61K31/52 ,  A61K31/42 ,  A61P37/06

摘要： Embodiments disclosed herein relate to compositions and methods for inducing transplantation tolerance using immunomodulation agents. In certain embodiments compositions and methods disclosed herein, concern administering a composition including, but not limited to, anti-CD3 immunotoxin and administering a composition including, but not limited to, peripheral blood cells obtained from a donor of an organ, tissue or cells to be transplanted. In some embodiments, compositions and methods disclosed here can be used for modulating B- and/or T-cell-mediated immunity and/or rejection by reducing or eliminating anti-donor antibody production. Other embodiments concern modulating T-cell production in a subject preparing for, undergoing organ, tissue or cellular transplantation; or having or expected of developing GvHD for reducing the risk of, preventing or treating rejection or GvHD. In certain embodiments, combination compositions of anti-CD3 immunotoxin and peripheral blood cells from a donor are contemplated.