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公开(公告)号：US20190142799A1
公开(公告)日：2019-05-16
申请号：US16300421
申请日：2017-05-12
Applicant: The Regents of the University of Michigan
Inventor： Jolanta Grembecka , Tomasz Cierpicki , David Rogawski , Dmitry Borkin , Szymon Klossowski , Jin Zhuang , Deanna Montgomery
IPC: A61K31/404 , A61P35/02
Abstract: Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
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