公开(公告)号：US10227567B2

公开(公告)日：2019-03-12

申请号：US15258419

申请日：2016-09-07

Applicant: The Regents of the University of Michigan

Inventor： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

IPC: C12N5/095 ,  A01K67/027 ,  G01N33/50 ,  G01N33/574 ,  A61K39/395 ,  C12Q1/6886 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

公开(公告)号：US20150132294A1

公开(公告)日：2015-05-14

申请号：US14534354

申请日：2014-11-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Michael F. Clarke ,  Muhammad Al-Hajj

IPC: C07K16/22 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC classification number: A61K39/39558 ,  A61K31/337 ,  A61K38/005 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/3015 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/57415 ,  G01N33/57484

Abstract: The present invention relates to compositions and methods for characterizing, regulating, diagnosing, and treating cancer. For example, the present invention provides compositions and methods for inhibiting tumorigenesis of certain classes of cancer cells, including breast cancer cells and preventing metastasis. The present invention also provides systems and methods for identifying compounds that regulate tumorigenesis.

Abstract translation: 本发明涉及用于表征，调节，诊断和治疗癌症的组合物和方法。 例如，本发明提供抑制某些类型的癌细胞（包括乳腺癌细胞）和预防转移的肿瘤发生的组合物和方法。 本发明还提供用于鉴定调节肿瘤发生的化合物的系统和方法。

公开(公告)号：US09089556B2

公开(公告)日：2015-07-28

申请号：US13795381

申请日：2013-03-12

Applicant: The Regents of the University of Michigan

Inventor： Michael F. Clarke ,  Max S. Wicha ,  Muhammad Al-Hajj

IPC: C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A01K67/027 ,  C12N5/095 ,  G01N33/50 ,  G01N33/574 ,  C12Q1/68 ,  C07K14/705 ,  C07K14/71 ,  A61K39/00

CPC classification number: C12N5/0695 ,  A01K67/0271 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/5158 ,  C07K14/705 ,  C07K14/70585 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/30 ,  C12N2501/42 ,  C12N2503/00 ,  C12N2503/02 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/57492

Abstract: The invention provides methods for treating cancer via administering to a patient having a solid tumor a therapeutically effective amount of an antibody against Delta-like ligand 4(Dll4) or other Notch pathway components. The solid tumor may comprise solid tumor stem cells.

Abstract translation: 本发明提供了通过向具有实体瘤的患者施用治疗有效量的针对三角形配体4（D114）或其它Notch途径组分的抗体来治疗癌症的方法。 实体瘤可包含实体肿瘤干细胞。

公开(公告)号：US20170175083A1

公开(公告)日：2017-06-22

申请号：US15258419

申请日：2016-09-07

Applicant: The Regents of the University of Michigan

Inventor： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

IPC: C12N5/095

CPC classification number: C12N5/0695 ,  A01K67/0271 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/5158 ,  C07K14/705 ,  C07K14/70585 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/30 ,  C12N2501/42 ,  C12N2503/00 ,  C12N2503/02 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/57492

Abstract: A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

公开(公告)号：US20170119880A1

公开(公告)日：2017-05-04

申请号：US15172619

申请日：2016-06-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Michael F. Clarke ,  Muhammad Al-Hajj

IPC: A61K39/395 ,  C07K16/30 ,  A61K31/337 ,  C07K16/28 ,  A61K45/06

CPC classification number: A61K39/39558 ,  A61K31/337 ,  A61K38/005 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/22 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/3015 ,  C07K2317/76 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/57415 ,  G01N33/57484

Abstract: The present invention relates to compositions and methods for characterizing, regulating, diagnosing, and treating cancer. For example, the present invention provides compositions and methods for inhibiting tumorigenesis of certain classes of cancer cells, including breast cancer cells and preventing metastasis. The present invention also provides systems and methods for identifying compounds that regulate tumorigenesis.