公开(公告)号：US10227567B2

公开(公告)日：2019-03-12

申请号：US15258419

申请日：2016-09-07

Applicant: The Regents of the University of Michigan

Inventor： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

IPC: C12N5/095 ,  A01K67/027 ,  G01N33/50 ,  G01N33/574 ,  A61K39/395 ,  C12Q1/6886 ,  C07K14/705 ,  C07K14/71 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.

公开(公告)号：US20170175083A1

公开(公告)日：2017-06-22

申请号：US15258419

申请日：2016-09-07

Applicant: The Regents of the University of Michigan

Inventor： Michael F. Clarke ,  Sean J. Morrison ,  Max S. Wicha ,  Muhammad Al-Hajj

IPC: C12N5/095

CPC classification number: C12N5/0695 ,  A01K67/0271 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/5152 ,  A61K2039/5158 ,  C07K14/705 ,  C07K14/70585 ,  C07K14/71 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/30 ,  C12N2501/42 ,  C12N2503/00 ,  C12N2503/02 ,  C12Q1/6886 ,  G01N33/5011 ,  G01N33/57492

Abstract: A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. This discovery is the basis for solid tumor stem cell compositions, methods for distinguishing functionally different populations of tumor cells, methods for using these tumor cell populations for studying the effects of therapeutic agents on tumor growth, and methods for identifying and testing novel anti-cancer therapies directed to solid tumor stem cells.