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公开(公告)号：US10814146B2
公开(公告)日：2020-10-27
申请号：US16143144
申请日：2018-09-26
申请人： The Research Foundation for State University of NY , Board of Regents, The University of Texas System
摘要： A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.
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公开(公告)号：US11511136B2
公开(公告)日：2022-11-29
申请号：US16764362
申请日：2018-11-16
发明人： F. Avraham Dilmanian
摘要： A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least 0.05 mm, and optionally administering schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.
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公开(公告)号：US20200276457A1
公开(公告)日：2020-09-03
申请号：US16764362
申请日：2018-11-16
发明人： F. Avraham Dilmanian
摘要： A method for treating damaged peripheral nerves of a subject includes irradiating at least a portion of the damaged PNs with an array of x-ray microbeams having an in-beam dose sufficient to at least initiate demyelination, each of the microbeams being no greater than 0.7 mm in thickness, and separated for tissue sparing, e.g., by at least 0.05 mm, and optionally administering schwann cell progenitors (SCPs) to the irradiated portion to remyelination before or after irradiating. In-beam dose may be between about 30 to 200 Gy. The method may include irradiating using an x-ray tube of a CT scanner having a multi-aperture collimator mounted thereto and on/near the subject. The SCPs may be adult rat olfactory sphere cells or neural stem cells.
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公开(公告)号：US20200289851A1
公开(公告)日：2020-09-17
申请号：US16760819
申请日：2018-11-06
摘要： A system and method for delivering microbeam radiation therapy (MRT) includes a computed tomography scanner configured to generate tomographic images of a subject, or patient, which includes imaging apparatus, a gantry with an opening for positioning the patient therein, an axis of rotation around which the gantry rotates, and an x-ray source mounted to and rotatable with the gantry. The system includes a bed for patient positioning within the opening and a multi-slit collimator removably mounted downstream of the x-ray source for delivering an array of microbeams of MRT to a targeted portion of the patient. Switching between MRT and CT is provided, and MRT modes of operation include a stationary mode, and continuous and step-wise rotational modes.
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公开(公告)号：US20190022423A1
公开(公告)日：2019-01-24
申请号：US16143144
申请日：2018-09-26
摘要： A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.
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公开(公告)号：US11628312B2
公开(公告)日：2023-04-18
申请号：US16760819
申请日：2018-11-06
摘要： A system and method for delivering microbeam radiation therapy (MRT) includes a computed tomography scanner (“CT”) configured to generate tomographic images of a subject, or patient, the scanner including an imaging apparatus, a gantry with an opening for positioning the patient therein, an axis of rotation around which the gantry rotates, and an x-ray source mounted to and rotatable with the gantry. The system includes a bed for patient positioning within the gantry opening and a multi-slit collimator removably mounted downstream of the x-ray source for delivering an array of microbeams of MRT to a targeted portion of the patient. Switching between MRT and CT is provided, and MRT modes of operation include a stationary mode, and continuous and step-wise rotational modes.
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公开(公告)号：US09962556B2
公开(公告)日：2018-05-08
申请号：US15318581
申请日：2015-06-24
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , Avraham Dilmanian , Sunil Krishnan , John Eley
发明人： F. Avraham Dilmanian , Sunil Krishnan , John Eley
CPC分类号： A61N5/06 , A61N5/1045 , A61N5/1084 , A61N2005/1087
摘要： A method for delivering therapeutic light ion radiation to a target volume of a subject, wherein the target volume is located at a predetermined depth from the skin, includes irradiating a surface of the skin with an array of light ion minibeams comprising parallel, spatially distinct minibeams at the surface in an amount and spatially arranged and sized to maintain a tissue-sparing effect from the skin to a proximal side of the target volume, and to merge into a solid beam at a proximal side of the target volume. A gap between the parallel, spatially distinct minibeams at the surface and a species of light ions forming the minibeams are selected such that the array merges into a solid beam at a predetermined beam energy, and across all energies for Bragg-peak spreading, at a proximal side of the target volume.
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