公开(公告)号：US10814146B2

公开(公告)日：2020-10-27

申请号：US16143144

申请日：2018-09-26

申请人： The Research Foundation for State University of NY ,  Board of Regents, The University of Texas System

发明人： F. Avraham Dilmanian ,  Sunil Krishnan ,  John Gordon Eley

IPC分类号： A61N5/10 ,  A61B6/06

摘要： A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.

公开(公告)号：US20190022423A1

公开(公告)日：2019-01-24

申请号：US16143144

申请日：2018-09-26

申请人： The Research Foundation for State University of NY

发明人： F. Avraham Dilmanian ,  Sunil Krishnan ,  John Gordon Eley

IPC分类号： A61N5/10 ,  A61B6/06

摘要： A method for delivering therapeutic radiation to a target includes positioning a multi-aperture collimator on the skin within a trajectory of orthovoltage x-rays directed at the target, thus generating an array of minibeams, each of width between 0.1 mm to 0.6 mm. The skin is irradiated with the array. An effective beam of therapeutic radiation, which may be a solid beam, is delivered to the target at a predetermined tissue depth by merging adjacent orthovoltage x-ray minibeams sufficiently to form the effective beam. The effective beam may be formed proximal to the target. The depth at which the effective, preferably, solid, beam is formed is controlled by varying one or more of the spacing of the minibeams in the array, the minibeam width, the distance from the x-ray source to the collimator, and the x-ray source spot size. Planar minibeams can be arc-scanned while continuously modulating beam shape and intensity.

公开(公告)号：US09962556B2

公开(公告)日：2018-05-08

申请号：US15318581

申请日：2015-06-24

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  Avraham Dilmanian ,  Sunil Krishnan ,  John Eley

发明人： F. Avraham Dilmanian ,  Sunil Krishnan ,  John Eley

IPC分类号： A61N5/06 ,  A61N5/10 ,  G21K5/04

CPC分类号： A61N5/06 ,  A61N5/1045 ,  A61N5/1084 ,  A61N2005/1087

摘要： A method for delivering therapeutic light ion radiation to a target volume of a subject, wherein the target volume is located at a predetermined depth from the skin, includes irradiating a surface of the skin with an array of light ion minibeams comprising parallel, spatially distinct minibeams at the surface in an amount and spatially arranged and sized to maintain a tissue-sparing effect from the skin to a proximal side of the target volume, and to merge into a solid beam at a proximal side of the target volume. A gap between the parallel, spatially distinct minibeams at the surface and a species of light ions forming the minibeams are selected such that the array merges into a solid beam at a predetermined beam energy, and across all energies for Bragg-peak spreading, at a proximal side of the target volume.